Presentation is loading. Please wait.

Presentation is loading. Please wait.

Monocyte recruitment in venous thrombus resolution

Published byHà Minh Loan Modified over 5 years ago

Similar presentations

Presentation on theme: "Monocyte recruitment in venous thrombus resolution"— Presentation transcript:

1 Monocyte recruitment in venous thrombus resolution
Tahir Ali, MRCS, Julia Humphries, PhD, Kevin Burnand, Barbara Sawyer, Christina Bursill, PhD, Keith Channon, David Greaves, PhD, Barrett Rollins, MD, Israel F. Charo, MD, PhD, Alberto Smith, PhD  Journal of Vascular Surgery  Volume 43, Issue 3, Pages (March 2006) DOI: /j.jvs Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 A, Fluorescence activated cell sorting analysis of peritoneal lavage cells demonstrates the CD4+/CD3− macrophage population in the upper left-hand quadrant. B, Peritoneal lavage fluid cytospin shows an abundance of mononuclear cells (arrows) stained by the rat macrophage marker, ED1 (brown stain, ×100 original magnification). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 125I-monocyte chemotactic protein 1 distribution in rat tissues for up to 7 days after direct injection into thrombus. IVC, Inferior vena cava. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Dose effect of monocyte chemotactic protein 1 (MCP1) (ng) on (A) recanalization and (B) thrombus size 7-days after thrombus induction. Values are ± SEM. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 A, Longitudinal study of thrombus resolution in MCP−/− mice (grey circles) and wild-type controls (black circles) and in (B) CCR2−/− mice (grey circles) and wild-type controls (black circles). *Denotes intergroup significance (P < .05). Values are ± SEM. ANOVA, Analysis of variance. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

6 Fig 5 A, Section of liver from ad.EGFP-treated mouse showing successful gene adenoviral transfection and EGFP expression (green fluorescence arrows, ×100 original magnification). B, Western blot of from five ad.35K transfected mice. The 35K protein and plasma from ad.EGFP treated animal were used as positive and negative controls respectively. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

7 Fig 6 The effect of vaccinia virus-derived 35Kd protein blockade of C-C chemokines on (A) thrombus size and (B) thrombus recanalization harvested 14 days after tail vein gene transfer. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Download ppt "Monocyte recruitment in venous thrombus resolution"

Similar presentations

Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis  Yunjian Zhang, PhD, MD, Hanping Shi, PhD, MD, Wenjian.

Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis  Yunjian Zhang, PhD, MD, Hanping Shi, PhD, MD, Wenjian.
Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: Roles of endothelial nitric oxide synthase and endothelial.

Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: Roles of endothelial nitric oxide synthase and endothelial.
Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice  Daniël Eefting,

Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice  Daniël Eefting,
Without prejudice Journal of Vascular Surgery

Without prejudice Journal of Vascular Surgery
Experimental pulmonary embolism: Effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin  John E. Rectenwald,

Experimental pulmonary embolism: Effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin  John E. Rectenwald,
Vein wall re-endothelialization after deep vein thrombosis is improved with low- molecular-weight heparin  Daria K. Moaveni, MD, Erin M. Lynch, MS, Cathy.

Vein wall re-endothelialization after deep vein thrombosis is improved with low- molecular-weight heparin  Daria K. Moaveni, MD, Erin M. Lynch, MS, Cathy.
Primary leiomyosarcoma of the inferior vena cava: Reports of infrarenal and suprahepatic caval involvement  Michael N. Tameo, MD, Keith D. Calligaro,

Primary leiomyosarcoma of the inferior vena cava: Reports of infrarenal and suprahepatic caval involvement  Michael N. Tameo, MD, Keith D. Calligaro,
Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and tested in the elastase model of abdominal aortic aneurysm in rats 

Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and tested in the elastase model of abdominal aortic aneurysm in rats 
Yi-kuan Chen, MD, Xue-mei Jiang, MSc, Jian-ping Gong, MD 

Yi-kuan Chen, MD, Xue-mei Jiang, MSc, Jian-ping Gong, MD 
Elevation of hemopexin-like fragment of matrix metalloproteinase-2 tissue levels inhibits ischemic wound healing and angiogenesis  April E. Nedeau, MD,

Elevation of hemopexin-like fragment of matrix metalloproteinase-2 tissue levels inhibits ischemic wound healing and angiogenesis  April E. Nedeau, MD,
Volume 69, Issue 6, Pages (March 2006)

Volume 69, Issue 6, Pages (March 2006)
Bedside vena cava filter placement with intravascular ultrasound: A simple, accurate, single venous access method  Donald L. Jacobs, MD, Raghunandan L.

Bedside vena cava filter placement with intravascular ultrasound: A simple, accurate, single venous access method  Donald L. Jacobs, MD, Raghunandan L.
Khanjan Baxi, BS, Samir K. Shah, MD, Daniel G. Clair, MD 

Khanjan Baxi, BS, Samir K. Shah, MD, Daniel G. Clair, MD 
Hyperglycemia limits experimental aortic aneurysm progression

Hyperglycemia limits experimental aortic aneurysm progression
Vascular endothelial growth factor naked DNA gene transfer enhances thrombus recanalization and resolution  Matthew Waltham, MA, PhD, Kevin Burnand, MS,

Vascular endothelial growth factor naked DNA gene transfer enhances thrombus recanalization and resolution  Matthew Waltham, MA, PhD, Kevin Burnand, MS,
Gale Tang, MD, David N. Charo, Rong Wang, PhD, Israel F

Gale Tang, MD, David N. Charo, Rong Wang, PhD, Israel F
Tissue engineering applications to vascular bypass graft development: The use of adipose-derived stem cells  Paul DiMuzio, MD, Thomas Tulenko, PhD  Journal.

Tissue engineering applications to vascular bypass graft development: The use of adipose-derived stem cells  Paul DiMuzio, MD, Thomas Tulenko, PhD  Journal.
Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model  Jianping Dai, MD, PhD, Liliane.

Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model  Jianping Dai, MD, PhD, Liliane.
Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice  Daniël Eefting,

Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice  Daniël Eefting,
Jeanwan Kang, MD, Hassan Albadawi, MD, Virendra I. Patel, MD, Thomas A

Jeanwan Kang, MD, Hassan Albadawi, MD, Virendra I. Patel, MD, Thomas A

Similar presentations

Ads by Google