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Molecular Aspects of Melanocytic Dysplastic Nevi

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Presentation on theme: "Molecular Aspects of Melanocytic Dysplastic Nevi"— Presentation transcript:

1 Molecular Aspects of Melanocytic Dysplastic Nevi
Mahmoud Rezk Abd-Elwahed Hussein, Gary Stewart Wood  The Journal of Molecular Diagnostics  Volume 4, Issue 2, Pages (May 2002) DOI: /S (10) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 Histological appearance of melanocytic dysplastic nevus (A) and cutaneous malignant melanoma (B). The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 The reported frequency of microsatellite instability (MSI) and loss of heterozygosity (LOH) on several chromosomal arms in melanocytic dysplastic nevi. The bars compare the frequency of these genetic changes among the different studies The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

4 Figure 3 Genetic changes in melanocytic dysplastic nevi. Left:Microsatellite instability (MSI), with the arrowhead indicating the appearance of a novel band in the tumor (T) DNA as compared to DNA from the normal tissues (N). Right:Loss of heterozygosity (LOH) in the tumor DNA, with the arrowhead indicating loss of upper allele in the tumor. The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

5 Figure 4 Immunohistochemical staining of MMR proteins in melanocytic dysplastic nevi (MDN). A:hMLH1 expression in the normal epidermis. Note the nuclear expression pattern (arrow):B: hMSH2 expression in MDN. Positively (arrow) and negatively (arrowhead) stained cells are observed in both MDN and CMM. The Journal of Molecular Diagnostics 2002 4, 71-80DOI: ( /S (10) ) Copyright © 2002 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

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