Presentation is loading. Please wait.

Presentation is loading. Please wait.

Gene Expression Screening of Salivary Gland Neoplasms

Published byHandoko Tedjo Modified over 6 years ago

Similar presentations

Presentation on theme: "Gene Expression Screening of Salivary Gland Neoplasms"— Presentation transcript:

1 Gene Expression Screening of Salivary Gland Neoplasms
Shin-ichiro Maruya, Hyung-Woo Kim, Randal S. Weber, Jack J. Lee, Merril Kies, Mario A. Luna, John G. Batsakis, Adel K. El-Naggar  The Journal of Molecular Diagnostics  Volume 6, Issue 3, Pages (August 2004) DOI: /S (10) Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 Example of comparative data analysis using the t-statistic and the mean of the gene expression for salivary gland tumors relative to normal tissue. The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) ) Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 Heat map of 49 genes selected to classify ACCs and other carcinomas. Expression levels are relative to matched normal salivary gland tissue. The colors ranging from red to green correspond to increased and decreased gene expression. P11 to P6: ACC; P21.1 to P23.1: MEC; P31.1 to P33.1: ACI; P41.1 to P43.1: SDC. The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) ) Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

4 Figure 3 Heat map of 17 genes selected to classify ACC-major and ACC-minor. Expression levels are relative to matched normal salivary gland tissue. The colors ranging from red to green correspond to increased and decreased gene expression. P11 to P13: ACC-major; P14 to P16: ACC-minor. The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) ) Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

5 Figure 4 Results of relative gene expression of ICAM5 under the endogenous control of β-actin in normal salivary gland tissue, PMA, and ACC derived from major salivary gland (ACC-major) and minor salivary gland (ACC-minor). The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) ) Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

6 Figure 5 Representative graph of quantitative RT-PCR for ICAM5 and β-actin as an endogenous control in normal salivary gland (A) and ACC (B). The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) ) Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

7 Figure 6 Photomicrograph of VHL-immunostaining in normal parotid gland with faint cytoplasmic staining in small duct (A), negative staining in ACI (B), and strong cytoplasmic staining in two different SDCs (C and D). The Journal of Molecular Diagnostics 2004 6, DOI: ( /S (10) ) Copyright © 2004 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Download ppt "Gene Expression Screening of Salivary Gland Neoplasms"

Similar presentations

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.
Nine Novel Germline Gene Variants in the RET Proto-Oncogene Identified in Twelve Unrelated Cases Syed A. Ahmed, Karen Snow-Bailey, W. Edward Highsmith,

Nine Novel Germline Gene Variants in the RET Proto-Oncogene Identified in Twelve Unrelated Cases Syed A. Ahmed, Karen Snow-Bailey, W. Edward Highsmith,
Telomerase Activity and Expression of Telomerase RNA Component and Telomerase Catalytic Subunit Gene in Cervical Cancer Kenji Nakano, Elizabeth Watney,

Telomerase Activity and Expression of Telomerase RNA Component and Telomerase Catalytic Subunit Gene in Cervical Cancer Kenji Nakano, Elizabeth Watney,
CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.

CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.
Quantification of Parvovirus B19 DNA Using COBAS AmpliPrep Automated Sample Preparation and LightCycler Real-Time PCR Stefan Schorling, Gunnar Schalasta,

Quantification of Parvovirus B19 DNA Using COBAS AmpliPrep Automated Sample Preparation and LightCycler Real-Time PCR Stefan Schorling, Gunnar Schalasta,
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.

Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.
Accurate Molecular Characterization of Formalin-Fixed, Paraffin-Embedded Tissues by microRNA Expression Profiling Anna E. Szafranska, Timothy S. Davison,

Accurate Molecular Characterization of Formalin-Fixed, Paraffin-Embedded Tissues by microRNA Expression Profiling Anna E. Szafranska, Timothy S. Davison,
Yoshitsugu Mitani, Jie Li, Randal S. Weber, Scott L. Lippman, Elsa R

Yoshitsugu Mitani, Jie Li, Randal S. Weber, Scott L. Lippman, Elsa R
Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation  Gisela Keller, Holger Vogelsang,

Diffuse Type Gastric and Lobular Breast Carcinoma in a Familial Gastric Cancer Patient with an E-Cadherin Germline Mutation  Gisela Keller, Holger Vogelsang,
Statistical Considerations for Immunohistochemistry Panel Development after Gene Expression Profiling of Human Cancers  Rebecca A. Betensky, Catherine.

Statistical Considerations for Immunohistochemistry Panel Development after Gene Expression Profiling of Human Cancers  Rebecca A. Betensky, Catherine.
Tracy I. George, Joanna E. Wrede, Charles D. Bangs, Athena M

Tracy I. George, Joanna E. Wrede, Charles D. Bangs, Athena M
A Strategy to Find Suitable Reference Genes for miRNA Quantitative PCR Analysis and Its Application to Cervical Specimens  Iris Babion, Barbara C. Snoek,

A Strategy to Find Suitable Reference Genes for miRNA Quantitative PCR Analysis and Its Application to Cervical Specimens  Iris Babion, Barbara C. Snoek,
Promoter Methylation and Differential Expression of π-Class Glutathione S-Transferase in Endometrial Carcinoma  Queeny K.Y. Chan, Ui-Soon Khoo, Kelvin.

Promoter Methylation and Differential Expression of π-Class Glutathione S-Transferase in Endometrial Carcinoma  Queeny K.Y. Chan, Ui-Soon Khoo, Kelvin.
Hybrid Model Integrating Immunohistochemistry and Expression Profiling for the Classification of Carcinomas of Unknown Primary Site  Barbara A. Centeno,

Hybrid Model Integrating Immunohistochemistry and Expression Profiling for the Classification of Carcinomas of Unknown Primary Site  Barbara A. Centeno,
A Quantitative Reverse Transcriptase-Polymerase Chain Reaction Assay to Identify Metastatic Carcinoma Tissue of Origin  Dimitri Talantov, Jonathan Baden,

A Quantitative Reverse Transcriptase-Polymerase Chain Reaction Assay to Identify Metastatic Carcinoma Tissue of Origin  Dimitri Talantov, Jonathan Baden,
Bongyong Lee, Joseph Mazar, Muhammad N

Bongyong Lee, Joseph Mazar, Muhammad N
Molecular Diagnosis of Necrotizing Fasciitis by 16S rRNA Gene Sequencing and Superantigen Gene Detection  Kenneth L. Muldrew, Jean F. Simpson, Charles.

Molecular Diagnosis of Necrotizing Fasciitis by 16S rRNA Gene Sequencing and Superantigen Gene Detection  Kenneth L. Muldrew, Jean F. Simpson, Charles.
Identification and Characterization of Optimal Gene Expression Markers for Detection of Breast Cancer Metastasis  John Backus, Todd Laughlin, Yixin Wang,

Identification and Characterization of Optimal Gene Expression Markers for Detection of Breast Cancer Metastasis  John Backus, Todd Laughlin, Yixin Wang,
Genome-Wide Identification and Validation of a Novel Methylation Biomarker, SDC2, for Blood-Based Detection of Colorectal Cancer  TaeJeong Oh, Nayoung.

Genome-Wide Identification and Validation of a Novel Methylation Biomarker, SDC2, for Blood-Based Detection of Colorectal Cancer  TaeJeong Oh, Nayoung.
Diagnostic Application of an Extensive Gene Panel for Leber Congenital Amaurosis with Severe Genetic Heterogeneity  Moon-Woo Seong, Soo Hyun Seo, Young.

Diagnostic Application of an Extensive Gene Panel for Leber Congenital Amaurosis with Severe Genetic Heterogeneity  Moon-Woo Seong, Soo Hyun Seo, Young.

Similar presentations

Ads by Google