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Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts  Heung-Woo Park, MD, PhD,

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Presentation on theme: "Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts  Heung-Woo Park, MD, PhD,"— Presentation transcript:

1 Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts  Heung-Woo Park, MD, PhD, Bing Ge, MSc, Szeman Tse, MDCM, Elin Grundberg, PhD, Tomi Pastinen, MD, PhD, H. William Kelly, PharmD, Kelan G. Tantisira, MD, MPH  Journal of Allergy and Clinical Immunology  Volume 136, Issue 5, Pages e8 (November 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Position of identified SNPs and genes on chromosome 17q. A, Rs , rs , TCBD, and TUBG1. B, LD plot between rs and rs (HapMap CEPH population). C, Analysis of potential pathway interactions between TBCD and TUBG1 through GeneMania ( Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Correlations between cumulative dose of OCS and BMA stratified by the number of mutant alleles of rs and rs Regression lines of the whole population, subjects without any mutant alleles, subjects with 1 mutant allele, subjects with 2 mutant alleles, and subjects with 3 mutant alleles are shown. The slope obtained from simple linear regression analysis becomes steeper as the number of mutant alleles of the 2 SNPs increases. P values were obtained from Pearson correlation analysis. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Quantile-quantile and Manhattan plots for interaction results. A, Quantile-quantile plot. Red line, Genome-wide significance. B, Manhattan plot. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Correlations between cumulative dose of OCS and BMA stratified by genotype of rs A, Whole population, reference allele homozygotes, heterozygotes, and mutant allele homozygotes. B, Merge of individual regression lines. A slope obtained from simple linear regression analysis became steeper as the number of mutant alleles of the 2 SNPs increased. P values were obtained from Pearson correlation analysis. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E3 Correlations between cumulative dose of OCS and BMA stratified by genotype of rs A, Whole population, reference allele homozygotes, heterozygotes, and mutant allele homozygotes. B, Merge of individual regression lines. A slope obtained from simple linear regression analysis became steeper as the number of mutant alleles of the 2 SNPs increased. P values were obtained from Pearson correlation analysis. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E4 Correlations between cumulative dose of OCS and BMA stratified by number of mutant alleles of rs and rs (merge of individual regression lines). A slope obtained from simple linear regression analysis became steeper as the number of mutant alleles of the 2 SNPs increased. P values were obtained from Pearson correlation analysis. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E5 Comparison of BMA stratified by rs in asthmatic children without OCS bursts between those randomized to ICS and those randomized to placebo. Differences according to the treatment groups or genotypes of rs were not statistically significant. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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