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Clinical Presentation, Outcome, and Response to Therapy Among Patients With Acute Exacerbation of Chronic Hepatitis C  Evangelista Sagnelli, Mariantonietta.

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Presentation on theme: "Clinical Presentation, Outcome, and Response to Therapy Among Patients With Acute Exacerbation of Chronic Hepatitis C  Evangelista Sagnelli, Mariantonietta."— Presentation transcript:

1 Clinical Presentation, Outcome, and Response to Therapy Among Patients With Acute Exacerbation of Chronic Hepatitis C  Evangelista Sagnelli, Mariantonietta Pisaturo, Maria Stanzione, Vincenzo Messina, Loredana Alessio, Caterina Sagnelli, Mario Starace, Giuseppe Pasquale, Nicola Coppola  Clinical Gastroenterology and Hepatology  Volume 11, Issue 9, Pages e11 (September 2013) DOI: /j.cgh Copyright © 2013 AGA Institute Terms and Conditions

2 Figure 1 Changes in fibrosis score between the first and second LB of patients in the case and control groups. Fibrosis score: stationary (grey columns), increased ≥2 (black columns), decreased ≥2 (white columns). P < .005, with an increased fibrosis score of 2 or greater, case group vs control group. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

3 Figure 2 Changes in necroinflammation (HAI) score between the first and second LB of patients in the case and control groups. Fibrosis score: stationary (grey columns), increased ≥2 (black columns), decreased ≥2 (white columns). P < .005, with increased HAI score of 2 or greater, case group vs control group. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

4 Figure 3 Serum ALT and bilirubin values throughout the observation in 4 patients (A−D) with acute exacerbation of CHC. G, grading; S, staging; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

5 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

6 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

7 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

8 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

9 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

10 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

11 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

12 Supplementary Figure 1 Serum ALT and bilirubin values throughout the observation in 50 patients (from patient 5 to patient 54) showing a single episode of acute exacerbation lasting less than 5 months. CC, IL-28B CC; CT, IL-28B CT; F, female; gen, genotype; G, grading; M, male; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

13 Supplementary Figure 2 Serum ALT and bilirubin values throughout the observation period in 6 patients (from patient 55 to patient 60) showing a single episode of acute exacerbation of CHC, lasting more than 6 months. CC, IL-28B CC; CT, IL-28B CT; G, grading; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

14 Supplementary Figure 3 Serum ALT and bilirubin values throughout the observation period in 6 patients (from patient 61 to patient 66) who showed 2 or more peaks of acute exacerbation of CHC. CC, IL-28B CC; CT, IL-28B CT; G, grading; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

15 Supplementary Figure 4 Serum ALT and bilirubin values throughout the observation period in 3 patients (from patient 67 to patient 69) who showed a rapid transition to cirrhosis. CC, IL-28B CC; CT, IL-28B CT; G, grading; S, staging; TT, IL-28 TT; UNV, upper normal value. Clinical Gastroenterology and Hepatology  , e11DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions


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