1. * *

2. *
Figure 2: * *

3. Prenatal RB1 mutation detection
Negative
0 % risk
Positive
100 % risk
No Screening required
Planned late preterm or early term delivery (36/37 weeks)
Flow chart
Clinical tumors at birth
20 % probability
No clinical tumors at birth
80 % probability
Manage per standard practice according to staging
OCT-guided posterior pole screening
No tumor detected
Clinical tumors detected
Invisible tumor detected
Tight follow up
Every 2weeks for 3 months
Every 3 weeks for 3 months
Every 4 weeks for 6 months
OCT-guided localization and photocoagulation
Invisible tumor detected