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CD8+ T cells from lupus-prone mice demonstrate substantial oligoclonality. CD8+ T cells from lupus-prone mice demonstrate substantial oligoclonality. (A–D)

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Presentation on theme: "CD8+ T cells from lupus-prone mice demonstrate substantial oligoclonality. CD8+ T cells from lupus-prone mice demonstrate substantial oligoclonality. (A–D)"— Presentation transcript:

1 CD8+ T cells from lupus-prone mice demonstrate substantial oligoclonality.
CD8+ T cells from lupus-prone mice demonstrate substantial oligoclonality. (A–D) Overview of total TCRβ rearrangements from wild type B6 and TLR7tg CD8+ T cells from Fig. 1. (A) The count of unique rearrangements in each sample that are in-frame and do not contain a stop codon. (B) The sum of templates for all productive rearrangements in the sample. (C) Clonality measure for each sample calculated over all productive rearrangements. (D) The fraction of productive in-frame templates among all templates. (E–G) The frequency (E) and sum (F) of the top 10 clones and the top clone (G) for each sample relative to all rearrangements. Error bars indicate mean + SD. ^p = 0.08, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ***p ≤ , by Student t test. Peter A. Morawski, and Silvia Bolland ImmunoHorizons 2019;3:61-70 ©2019 by American Association of Immunologists

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