1. Volume 13, Issue 4, Pages 237-243 (December 2006)
Reactive oxygen metabolites and anti-oxidative defenses in aspirin-induced gastric damage in rats: Gastroprotection by Vitamin E 
Mehrafarin Fesharaki, Ali Nasimi, Saloomeh Mokhtari, Roozbeh Mokhtari, Raana Moradian, Nooshin Amirpoor 
Pathophysiology 
Volume 13, Issue 4, Pages (December 2006)
DOI: /j.pathophys
Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

2. Fig. 1
PGE2 activity (pg/mg protein) at 3, 6, 9 and 24h after drug administration. ASA alone caused a significant decrease in PGE2 at all intervals compared with the control values. Administration of Vitamin E combined with ASA returned PGE2 towards the control values. (***) denotes a P<0.001 (t-test) compared with the corresponding interval of ASA+Vitamin E and the control group.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

3. Fig. 2
Myeloperoxidase (MPO) activity (U/mg protein) at 3, 6, 9 and 24h after the drug administration. Compared with the control values, ASA alone caused a significant increase in MPO at the first three intervals. Administration of Vitamin E combined with ASA returned MPO activity towards the control values. Compared with the control, Vitamin E alone decreased the MPO activity. (*) P<0.05, (**) P<0.01, (***) P<0.001 (t-test).
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

4. Fig. 3
Superoxide dismutase (SOD) activity (U/mg protein/min) at 3, 6, 9 and 24h after the drug administration. Compared with the control values, ASA alone caused a significant decrease in SOD activity at the all intervals. Administration of Vitamin E combined with ASA increased SOD activity significantly. Vitamin E alone, compared with the ASA+Vitamin E group, increased the SOD activity. (*) P<0.05, (***) P<0.001 (t-test).
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

5. Fig. 4
Total glutathione (GSH; nmol/mg protein) at 3, 6, 9 and 24h after the drug administration. Compared with the control values, ASA alone caused a significant decrease in GSH at all intervals. Administration of Vitamin E combined with ASA returned GSH towards the control values. Compared with the control, Vitamin E alone increased the GSH levels at the two first intervals. (**) P<0.01, (***) P<0.001 (t-test).
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

6. Fig. 5
Glutathione peroxidase activity (GSH-px; nmol/min/mg protein) at 3, 6, 9 and 24h after the drug administration. Compared with the control values, ASA alone caused a significant decrease in GSH-px at all intervals. Administration of Vitamin E combined with ASA returned GSH-px towards the control values. (**) P<0.01, (***) P<0.001 (t-test).
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions