1. Identifying human disease genes
Overview
Position independent methods
Positional cloning
Synteny
Drosophila mutants that are positional candidates for human disease genes

2. Identifying human disease genes
Overview of the process

4. Identifying human disease genes
Position independent methods
Complementation

6. Identifying human disease genes
Position dependent methods
CF gene chromosome jumping and walking

8. Identifying human disease genes
Mouse and human synteny

10. Identifying human disease genes
Drosophila and human disorders

12. Genetic testing
Overview
Examples CF gene

14. Genetic testing CF testing ARMs OLA Sequencing Heteroduplex screening
DGGE
Mismatch cleavage

21. Genetic testing
Oligonucleotide arrays

23. Genetic testing
Forensics
Paternity testing
Identification