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Naoki Fujimura, Baohui Xu, Haojun Xuan, Jiang J

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1 PC200. Immune Modulator FTY720 Suppresses Experimental Abdominal Aortic Aneurysms 
Naoki Fujimura, Baohui Xu, Haojun Xuan, Jiang J. Xiong, Hongping Deng, Sara A. Michie, Ronald L. Dalman  Journal of Vascular Surgery  Volume 61, Issue 6, Pages 171S-172S (June 2015) DOI: /j.jvs Copyright © Terms and Conditions

2 Fig FTY720 suppresses experimental abdominal aortic aneurysms (AAAs). Aneurysms were created via intra-aortic porcine pancreatic elastase (PPE) infusion in 10-week-old male C57BL/6J mice, which were daily treated with FYT720 (A-G) 3 days before (1 mg/k) or (H) 4 days after (0.3 and 1 mg/kg), PPE infusion. Influences on aneurysm formation and progression were evaluated via ultrasonography and histology. A, Ultrasound-measured aortic diameters before and after PPE infusion. Scores for (B) medial elastin degradation (Verhoeff staining) and (C) smooth muscle cell (SMC) destruction (SMC-α actin staining). Quantification of (D) CD68+ macrophages, (E) CD3+ T cells, (F) B220+ B cells, and (G) CD31+ blood vessels in aortic sections. H, Changes in aortic diameters in mice with existing AAAs after FTY720 or vehicle treatment. ACS, Aortic cross-section. All data are mean and standard deviation from six to seven mice in each group. *P < .05 and **P < .01 compared with vehicle treatment. Journal of Vascular Surgery  , 171S-172SDOI: ( /j.jvs ) Copyright © Terms and Conditions

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