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HMGA2, MicroRNAs, and Stem Cell Aging

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Presentation on theme: "HMGA2, MicroRNAs, and Stem Cell Aging"— Presentation transcript:

1 HMGA2, MicroRNAs, and Stem Cell Aging
Scott M. Hammond, Norman E. Sharpless  Cell  Volume 135, Issue 6, Pages (December 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 HMGA2 and let-7 in Mammalian Development
MicroRNAs (miRNAs) are generated as long primary transcripts (pri-miRNAs) that are processed by the Drosha/DGC8 complex into pre-miRNAs. Further processing by the endoribonuclease Dicer produces the 22 nucleotide mature miRNAs. Production of the let-7 miRNA during development is regulated by the RNA binding protein Lin-28. Mature let-7 targets multiple genes, including HMGA2. This architectural transcription factor represses INK4a/ARF expression, possibly through the repression of JunB. Cell  , DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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