1. Volume 114, Issue 1, Pages 164-174 (January 1998)
Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat 
Ronald J. Sokol, James M. McKim, M.Colby Goff, Stephanie Z. Ruyle, Michael W. Devereaux, Derick Han, Lester Packer, Gregory Everson 
Gastroenterology 
Volume 114, Issue 1, Pages (January 1998)
DOI: /S (98)
Copyright © 1998 American Gastroenterological Association Terms and Conditions

2. Fig. 1
Histology of liver in rats 4 hours after IV bolus infusion of 10 μmol/100 g TCDC. (A) Portal tract inflammation and individual hepatocyte necrosis (arrow) are evident. (B) Intracellular, smooth globules (arrows) were present in predominantly periportal hepatocytes. Councilman bodies (arrowheads) are scattered throughout the hepatic lobule (H&E; original magnification 40×).
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions

3. Fig. 1
Histology of liver in rats 4 hours after IV bolus infusion of 10 μmol/100 g TCDC. (A) Portal tract inflammation and individual hepatocyte necrosis (arrow) are evident. (B) Intracellular, smooth globules (arrows) were present in predominantly periportal hepatocytes. Councilman bodies (arrowheads) are scattered throughout the hepatic lobule (H&E; original magnification 40×).
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions

4. Fig. 2
Comparison of (A) serum ALT and (B) hepatic mitochondrial lipid-conjugated dienes in four treatment groups. Significant reductions in ALT and lipid-conjugated dienes were observed in vitamin E–treated rats that received IV TCDC compared with those receiving TCDC alone. Lipid-conjugated diene values are expressed as the difference in absorbance at 233 nm/mg lipid between experimental rats and the mean of the control (Contr) rats. Numbers in parentheses refer to number of rats tested in each group. *P < 0.05 vs. TCDC group.
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions

5. Fig. 3
Relationship between serum ALT and lipid-conjugated dienes (expressed as difference in absorbance at 233 nm/mg lipid between experimental rats and the mean of the control rats) calculated by polynomial linear regression analysis. Curve defined by y = × − E−8×2. r = 0.651; P <
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions

6. Fig. 4
Representative histology from liver specimens obtained 4 hours after IV infusion of TCDC or saline, with or without treatment with vitamin E. (A) Liver from rat after TCDC treatment showing significant hepatocellular necrosis (arrowheads) and portal and lobular inflammation. (B) Liver from a rat receiving both vitamin E and TCDC, showing marked reduction of abnormal findings present in A. Arrowhead indicates hepatocellular necrosis. (C) Liver from rat receiving IV normal saline, showing no histological abnormalities. (D) Liver from rat receiving IV normal saline and vitamin E, showing no abnormalities (H&E; original magnification 40×).
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions

7. Fig. 4
Representative histology from liver specimens obtained 4 hours after IV infusion of TCDC or saline, with or without treatment with vitamin E. (A) Liver from rat after TCDC treatment showing significant hepatocellular necrosis (arrowheads) and portal and lobular inflammation. (B) Liver from a rat receiving both vitamin E and TCDC, showing marked reduction of abnormal findings present in A. Arrowhead indicates hepatocellular necrosis. (C) Liver from rat receiving IV normal saline, showing no histological abnormalities. (D) Liver from rat receiving IV normal saline and vitamin E, showing no abnormalities (H&E; original magnification 40×).
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions

8. Fig. 4
Representative histology from liver specimens obtained 4 hours after IV infusion of TCDC or saline, with or without treatment with vitamin E. (A) Liver from rat after TCDC treatment showing significant hepatocellular necrosis (arrowheads) and portal and lobular inflammation. (B) Liver from a rat receiving both vitamin E and TCDC, showing marked reduction of abnormal findings present in A. Arrowhead indicates hepatocellular necrosis. (C) Liver from rat receiving IV normal saline, showing no histological abnormalities. (D) Liver from rat receiving IV normal saline and vitamin E, showing no abnormalities (H&E; original magnification 40×).
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions

9. Fig. 4
Representative histology from liver specimens obtained 4 hours after IV infusion of TCDC or saline, with or without treatment with vitamin E. (A) Liver from rat after TCDC treatment showing significant hepatocellular necrosis (arrowheads) and portal and lobular inflammation. (B) Liver from a rat receiving both vitamin E and TCDC, showing marked reduction of abnormal findings present in A. Arrowhead indicates hepatocellular necrosis. (C) Liver from rat receiving IV normal saline, showing no histological abnormalities. (D) Liver from rat receiving IV normal saline and vitamin E, showing no abnormalities (H&E; original magnification 40×).
Gastroenterology  , DOI: ( /S (98) )
Copyright © 1998 American Gastroenterological Association Terms and Conditions