1. Obesity and Alcohol Synergize to Increase the Risk of Incident Hepatocellular Carcinoma in Men 
Rohit Loomba, Hwai-I. Yang, Jun Su, David Brenner, Uchenna Iloeje, Chien-Jen Chen 
Clinical Gastroenterology and Hepatology 
Volume 8, Issue 10, Pages e2 (October 2010)
DOI: /j.cgh
Copyright © 2010 AGA Institute Terms and Conditions

2. Figure 1
Risk of incident HCC is 3.1 (95% CI, 1.1–8.3) times higher in alcohol users who have a BMI of 30 kg/m2 or greater as compared with nonusers of alcohol with a BMI of less than 30 kg/m2, which is suggestive of multiplicative effect. This figure shows that obesity significantly augments the risk of incident HCC in alcohol users but not in nonusers.
Clinical Gastroenterology and Hepatology 2010 8, e2DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

3. Figure 2
This figure shows the incidence curves of development of HCC in the 4 BMI-alcohol categories. The y-axis depicts the proportion of individuals in each group who are developing HCC (0.1 representing 10% and 0.2 representing 20% of participants). The risk of incident HCC was highest in alcohol users with a BMI of 30 kg/m2 or greater.
Clinical Gastroenterology and Hepatology 2010 8, e2DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

4. Figure 3
Participants are classified into weight categories suggested by WHO for Asian populations. Normal weight is BMI less than 23 kg/m2, overweight is BMI of 23 to less than 25 kg/m2, obese includes BMI of 25 to less than 30 kg/m2, and extremely obese includes BMI of 30 kg/m2 or greater. This figure shows that risk of incident HCC increases as BMI dose increases only in alcohol users (P value for trend = .046).
Clinical Gastroenterology and Hepatology 2010 8, e2DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

5. Supplementary Figure 1
Joint effect of BMI categories and duration of alcohol use with risk of HCC. Participants are classified into weight categories suggested by WHO for Asian populations. Normal weight is BMI less than 23 kg/m2, overweight is BMI of 23 to less than 25 kg/m2, obese includes BMI of 25 to less than 30 kg/m2, and extremely obese includes BMI of 30 kg/m2 or greater. This figure shows that risk of incident HCC increases as BMI dose increases in individuals with 20 or more years of alcohol use (P value for trend = .006). Within each weight category, the risk of HCC increased with greater duration of alcohol use as well.
Clinical Gastroenterology and Hepatology 2010 8, e2DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

6. Supplementary Figure 2
Joint effect of BMI quartiles and alcohol use with risk of HCC in men. Participants are classified into quartiles of BMI: quartile 1 (lowest BMI: referent group) and quartile 4 (highest BMI category). This figure shows that risk of incident HCC increases as BMI dose increases only in alcohol users (P value for trend = .08).
Clinical Gastroenterology and Hepatology 2010 8, e2DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

7. Supplementary Figure 3
Joint effect of BMI quartiles and duration of alcohol use with risk of HCC in men. Participants are classified into quartiles of BMI: quartile 1 (lowest BMI: referent group) and quartile 4 (highest BMI category). This figure shows that risk of incident HCC increases as BMI dose increases in individuals with 20 or more years of alcohol use (P value for trend = .027). Within each weight category, the risk of HCC increased with greater duration of alcohol use except in the lowest quartile in which the effect of modification was clinically not significant.
Clinical Gastroenterology and Hepatology 2010 8, e2DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions