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Tamsulosin Oral Controlled Absorption System (OCAS) in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (LUTS/BPH):

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Presentation on theme: "Tamsulosin Oral Controlled Absorption System (OCAS) in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (LUTS/BPH):"— Presentation transcript:

1 Tamsulosin Oral Controlled Absorption System (OCAS) in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (LUTS/BPH): Efficacy and Tolerability in a Placebo and Active Comparator Controlled Phase 3a Study  Christopher R. Chapple, Salman H. Al-Shukri, Bernard Gattegno, Simon Holmes, José M. Martínez-Sagarra, Roberto M. Scarpa, Oncko B. van Vierssen Trip, Viktor Vik, Ingrid van der Putten-Slob  European Urology Supplements  Volume 4, Issue 2, Pages (February 2005) DOI: /j.eursup Copyright © 2004 Elsevier B.V. Terms and Conditions

2 Fig. 1 Flow diagram of the number of patients enrolled, randomised and completing the study per treatment group. European Urology Supplements 2005 4, 33-44DOI: ( /j.eursup ) Copyright © 2004 Elsevier B.V. Terms and Conditions

3 Fig. 2 Mean change in total I-PSS from baseline to endpoint (ITT).
European Urology Supplements 2005 4, 33-44DOI: ( /j.eursup ) Copyright © 2004 Elsevier B.V. Terms and Conditions

4 Fig. 3 Effect of treatment on mean total I-PSS over time (ITT).
European Urology Supplements 2005 4, 33-44DOI: ( /j.eursup ) Copyright © 2004 Elsevier B.V. Terms and Conditions

5 Fig. 4 Percentage of patients with all dizziness and abnormal ejaculation MedDRA coded terms combined (SAF). Abnormal ejaculation: p= for tamsulosin MR 0.4mg vs. placebo, p= for tamsulosin OCAS 0.8mg vs. placebo and p= for tamsulosin OCAS 0.8mg vs. tamsulosin OCAS 0.4mg. European Urology Supplements 2005 4, 33-44DOI: ( /j.eursup ) Copyright © 2004 Elsevier B.V. Terms and Conditions

6 Fig. 5 Mean change in supine SBP and DBP from baseline to 12 weeks of treatment (SAF). European Urology Supplements 2005 4, 33-44DOI: ( /j.eursup ) Copyright © 2004 Elsevier B.V. Terms and Conditions


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