1. K 305
21 May 03
03/05/21 1

2. E-C coupling in mammalian heart
03/05/21

3. E-C Coupling in the Heart
L-type Ca channel or DHPR
a1c or CaV1.2 subunit
SR Ca release channel or RyR
SERCA2A
Phospholamban (PLB)
NCX1.1
03/05/21 1

4. 03/05/21

5. Respiratory Section Website
Kinesiology 305 (03-2) Human Physiology I AQ5016
Course Outline
   
Respiratory Section Website
Schedule of Lectures
        
03/05/21

6. E-C Coupling in the Heart
L-type Ca channel or DHPR
a1c or CaV1.2 subunit
SR Ca release channel or RyR
SERCA2A
Phospholamban (PLB)
NCX1.1
03/05/21 1

7. E-C coupling in mammalian heart
03/05/21

8. E-C Coupling in the Heart
L-type Ca channel or DHPR
a1c or CaV1.2 subunit
SR Ca release channel or RyR
SERCA2A
Phospholamban (PLB)
NCX1.1
03/05/21 1

9. E-C coupling in mammalian heart
03/05/21

10. E-C Coupling in the Heart
L-type Ca channel or DHPR
a1c or CaV1.2 subunit
SR Ca release channel or RyR
SERCA2A
Phospholamban (PLB)
NCX1.1
03/05/21 1

11. E-C coupling in mammalian heart
03/05/21

12. E-C Coupling in the Heart
L-type Ca channel or DHPR
a1c or CaV1.2 subunit
SR Ca release channel or RyR
SERCA2A
Phospholamban (PLB)
NCX1.1
03/05/21 1

13. E-C coupling in mammalian heart
03/05/21

14. Regulation of E-C Coupling
SNS via the adrenergic b1 receptor
Gs- AC and PKA and phosphorylation of:
DHPR (b subunit) - increasing open probability
phospholamban -increasing SERCA2A activity
TnI - increasing off loading of Ca from TnC
RyR - increasing fractional release
03/05/21