Presentation is loading. Please wait.

Presentation is loading. Please wait.

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

Published byLesley Randall Modified over 5 years ago

Similar presentations

Presentation on theme: "DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate."— Presentation transcript:

1 DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. WT and KO mice were infected with LCMV Armstrong. (A) Short-lived effector (KLRG1+CD127−) and memory precursor (KLRG1−CD127+) cells were examined from blood at 1, 2, 4, 6 wk postinfection. Six weeks postinfection, splenocytes were analyzed for gp33-LCMV–specific total CD8+ T cells (B) or short-lived effector cells and memory precursor effector cells (C). (D) Splenocytes were stimulated in vitro with GP33, NP369, and GP276 peptides. Graphs show the frequency of IFN-γ effector CD8+ T cells. Data from two pooled experiments. (n = 8–9 in each group). *p < 0.05, **p < 0.01, ***p < ns, not significant. Erin M. Wesley et al. ImmunoHorizons 2018;2: Copyright © 2018 The Authors

Download ppt "DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate."

Similar presentations

Fig. 1. Level of Mac-1 expression on naive and recently activated LCMV GP33–41-specific T cells from TCR 318 transgenic mice. (A and B) Splenocytes from.

Fig. 1. Level of Mac-1 expression on naive and recently activated LCMV GP33–41-specific T cells from TCR 318 transgenic mice. (A and B) Splenocytes from.
Volume 45, Issue 2, Pages (August 2016)

Volume 45, Issue 2, Pages (August 2016)
Sustained Interactions between T Cell Receptors and Antigens Promote the Differentiation of CD4+ Memory T Cells  Chulwoo Kim, Theodore Wilson, Kael F.

Sustained Interactions between T Cell Receptors and Antigens Promote the Differentiation of CD4+ Memory T Cells  Chulwoo Kim, Theodore Wilson, Kael F.
Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection  Vladimir P. Badovinac,

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection  Vladimir P. Badovinac,
Volume 36, Issue 6, Pages (June 2012)

Volume 36, Issue 6, Pages (June 2012)
Volume 8, Issue 2, Pages (February 1998)

Volume 8, Issue 2, Pages (February 1998)
Hans-Peter Raué, Carol Beadling, Jennifer Haun, Mark K. Slifka 

Hans-Peter Raué, Carol Beadling, Jennifer Haun, Mark K. Slifka 
Volume 25, Issue 11, Pages (November 2017)

Volume 25, Issue 11, Pages (November 2017)
MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.
The role of CC chemokine receptor 5 in antiviral immunity

The role of CC chemokine receptor 5 in antiviral immunity
IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis  Stéphanie.

IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis  Stéphanie.
miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation
Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets.

Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets.
Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.

Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.
Volume 23, Issue 1, Pages (April 2018)

Volume 23, Issue 1, Pages (April 2018)
Volume 31, Issue 1, Pages (July 2009)

Volume 31, Issue 1, Pages (July 2009)
MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.

MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.
Prf1−/− mice exhibit increased immunopathology with prior CD8 T cell memory secondary to immunization. Prf1−/− mice exhibit increased immunopathology with.

Prf1−/− mice exhibit increased immunopathology with prior CD8 T cell memory secondary to immunization. Prf1−/− mice exhibit increased immunopathology with.
Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient mice. Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient.

Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient mice. Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient.
Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Similar presentations

Ads by Google