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Deregulated p21WAF1 Overexpression Impacts Survival of Surgically Resected Esophageal Squamous Cell Carcinoma Patients  Yih-Gang Goan, MD, Hon-Ki Hsu,

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Presentation on theme: "Deregulated p21WAF1 Overexpression Impacts Survival of Surgically Resected Esophageal Squamous Cell Carcinoma Patients  Yih-Gang Goan, MD, Hon-Ki Hsu,"— Presentation transcript:

1 Deregulated p21WAF1 Overexpression Impacts Survival of Surgically Resected Esophageal Squamous Cell Carcinoma Patients  Yih-Gang Goan, MD, Hon-Ki Hsu, MD, Huang-Chou Chang, MD, Yi-Ping Chou, MD, Ke-Hsin Chiang, MD, Jiin-Tsuey Cheng, PhD  The Annals of Thoracic Surgery  Volume 80, Issue 3, Pages (September 2005) DOI: /j.athoracsur Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Immunohistochemistry of p21 and p53 in esophageal squamous cell carcinomas. Nucleus stained p21 protein was seen (a) heterogeneously in tumor component (original magnification ×100) and (b) only in the para-basal layer of normal esophageal mucosa (original magnification ×100). The p53 protein expressed (c) prominently in nuclei of cancer cells (original magnification ×200), but not in (d) normal mucosa (original magnification ×100). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Patterns of DNA histogram. Diploid samples were regarded as those for which the histogram showed a single defined G0/G1 peak on the DNA histogram (A). The aneuploid samples were regarded as those for which the histograms presented a second G0/G1 peak in an unexpected location (B) or a clearly distinct additional G0/G1 peak with a small G2/M peak (C). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Kaplan-Meier survival estimation of surgically treated esophageal squamous cell carcinoma (ESCC) patients related to possible predictors. (A) Significant prognostic effect of pTNM stage for ESCC patients (p = 0.001). (B) The p21 overexpression significantly impacts on ESCC patients survival (p = 0.017, 250 and 467 days of median survival for positive and negative p21 overexpression respectively). (C) The p53 mutation status (p = 0.488), and (D) p53 immunohistochemistry (IHC) stain (p = 0.051) did not predict outcome of ESCC patients. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Kaplan-Meier survival estimation of p21 overexpression adjusted by p53 gene mutation status. (A) Overexpression of p21 significantly impacts patients’ survival when the p53 gene mutated (p = 0.035). The median survival was 314 days and 930 days for positive and negative p21 overexpression, respectively. (B) However, this dismal effect cannot be observed in p53 immunohistochemistry (IHC). (C) Under wild-type p53 gene control, p21 expression plays no significant effect on patients’ survival (p = 0.175). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

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