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Sperm Centrosomes: Kiss Your Asterless Goodbye, for Fertility’s Sake
Gerald Schatten, Tim Stearns Current Biology Volume 25, Issue 24, Pages R1178-R1181 (December 2015) DOI: /j.cub Copyright © 2015 Elsevier Ltd Terms and Conditions
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Figure 1 Reduction of the mammalian sperm centrosome, extrapolated from the findings presented in Khire et al. [2]. The complete centrosome (insert bottom left), with an embedded centriole pair, is the cell’s primary microtubule-organizing center. It is fully active and duplicates in spermatogonial stem cells prior to their entry into spermatogenesis. In primary and secondary spermatocytes, the centrioles start to lose their duplicative abilities. Mature sperm typically have a centriole, at times juxtaposed to a degenerated centriole remnant, near the implantation fossa between the sperm nucleus and midpiece. During spermiogenesis, as the round sperm nucleus elongates into the pyramidal shape, a majority of the cytoplasm is shed into the cytoplasmic droplet. The now elongated sperm, which has eliminated most of its pericentriolar material (PCM), including γ-tubulin, pericentrin and NuMA, still retains core centriolar molecules including centrin. Khire et al. [2] show that sperm maturation ultimately requires the destruction of both Asl/CEP152 and Plk4 targeted by the Slimb ubiquitin ligase in Drosophila and probably other animals as well. Investigations testing the accuracy of this model as well as the interdependence among the now dozens of centriole and centrosome proteins are worthy pursuits. (Main figure adapted from Martini, F.H., Timmons, M.J., Tallitsch, R.B. Human Anatomy, 7th edition © 2012, printed and electronically reproduced by permission of Pearson Education, Inc., New York. Insert at bottom left reprinted by permission from Macmillan Publishers Ltd: Bettencourt-Dias, M. and Glover D.M. Nat. Rev. Mol. Cell Biol. 8, 451–463 © 2007.) Current Biology , R1178-R1181DOI: ( /j.cub ) Copyright © 2015 Elsevier Ltd Terms and Conditions
![Figure 1 Reduction of the mammalian sperm centrosome, extrapolated from the findings presented in Khire et al. [2].](http://slideplayer.com./slide/15953649/88/images/2/Figure+1+Reduction+of+the+mammalian+sperm+centrosome%2C+extrapolated+from+the+findings+presented+in+Khire+et+al.+%5B2%5D..jpg "The complete centrosome (insert bottom left), with an embedded centriole pair, is the cell’s primary microtubule-organizing center. It is fully active and duplicates in spermatogonial stem cells prior to their entry into spermatogenesis. In primary and secondary spermatocytes, the centrioles start to lose their duplicative abilities. Mature sperm typically have a centriole, at times juxtaposed to a degenerated centriole remnant, near the implantation fossa between the sperm nucleus and midpiece. During spermiogenesis, as the round sperm nucleus elongates into the pyramidal shape, a majority of the cytoplasm is shed into the cytoplasmic droplet. The now elongated sperm, which has eliminated most of its pericentriolar material (PCM), including γ-tubulin, pericentrin and NuMA, still retains core centriolar molecules including centrin. Khire et al. [2] show that sperm maturation ultimately requires the destruction of both Asl/CEP152 and Plk4 targeted by the Slimb ubiquitin ligase in Drosophila and probably other animals as well. Investigations testing the accuracy of this model as well as the interdependence among the now dozens of centriole and centrosome proteins are worthy pursuits. (Main figure adapted from Martini, F.H., Timmons, M.J., Tallitsch, R.B. Human Anatomy, 7th edition © 2012, printed and electronically reproduced by permission of Pearson Education, Inc., New York. Insert at bottom left reprinted by permission from Macmillan Publishers Ltd: Bettencourt-Dias, M. and Glover D.M. Nat. Rev. Mol. Cell Biol. 8, 451–463 © 2007.) Current Biology , R1178-R1181DOI: ( /j.cub ) Copyright © 2015 Elsevier Ltd Terms and Conditions.")
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