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Recovery of ovarian activity in women with functional hypothalamic amenorrhea who were treated with cognitive behavior therapy Sarah L Berga, M.D., Marsha D Marcus, Ph.D., Tammy L Loucks, M.P.H., Stefanie Hlastala, M.S., Rebecca Ringham, M.A., Marijane A Krohn, Ph.D. Fertility and Sterility Volume 80, Issue 4, Pages (October 2003) DOI: /S (03)
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FIGURE 1 Body mass index (kg/m2) presented (A) individually, (B) by treatment subgroup (mean ± SEM), and (C) by recovery status in women with FHA before and after treatment with CBT or observation (OBS). (A) Filled circle, recovered with CBT; filled triangle, partially recovered with CBT; filled square, unrecovered with CBT; open circle, recovered during OBS; open triangle, partially recovered during OBS; open square, unrecovered during OBS. (B) Filled circle, CBT; open circle, OBS. (C) Filled circle, recovered; open circle, unrecovered. For observed vs. treated, repeated-measures analysis of variance (RM-ANOVA) P=.09. For recovered vs. unrecovered, RM-ANOVA P=.40. Berga. CBT restores ovarian activity in FHA.Fertil Steril 2003. Fertility and Sterility , DOI: ( /S (03) )
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FIGURE 2 Ovarian responses in women with FHA randomized to CBT (n = 8) or observation (OBS, n = 8), χ2 = 7.14, P=.03. Full recovery, filled bars; partial recovery, shaded bars; and anovulatory, open bars. Berga. CBT restores ovarian activity in FHA.Fertil Steril 2003. Fertility and Sterility , DOI: ( /S (03) )
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FIGURE 3 Estradiol (■) and P (○) levels in a woman with FHA who had return of ovulatory menstrual cycles while undergoing CBT and in a woman with FHA who was observed for 20 weeks and who remained anovulatory. Vaginal bleeding is indicated by down arrow. Berga. CBT restores ovarian activity in FHA.Fertil Steril 2003. Fertility and Sterility , DOI: ( /S (03) )
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