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Can U Turn ILC2s Up?  Paul A. Muller, Daniel Mucida  Cell 

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Presentation on theme: "Can U Turn ILC2s Up?  Paul A. Muller, Daniel Mucida  Cell "— Presentation transcript:

1 Can U Turn ILC2s Up?  Paul A. Muller, Daniel Mucida  Cell  Volume 171, Issue 4, Pages (November 2017) DOI: /j.cell Copyright © Terms and Conditions

2 Figure 1 Neuromedin U Amplification of ILC2 Responses
(A) At steady state, neuromedin receptor 1 (NMUR1)-expressing ILC2s are abundant in the lungs and small intestine. Within both tissues, ILC2s are closely associated with neuromedin U (NMU)-positive neuronal cell bodies and fibers. (B) Upon exposure to type 2 immune inducing organisms such as house dust mites and N. brasiliensis, neurons in the lungs and intestine release NMU through unknown mechanisms. Activation of ILC2 NMUR1 by NMU leads to increased numbers of ILC2s and ILC2 cytokine production. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

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