1. Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth trajectory 
César Díaz-García, M.D., Liza Johannesson, M.D., Ph.D., Ruijin Shao, Ph.D., Håkan Bilig, M.D., Ph.D., Mats Brännström, M.D., Ph.D. 
Fertility and Sterility 
Volume 102, Issue 6, Pages e1 (December 2014)
DOI: /j.fertnstert
Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
Histologic sections of uteri from pregnant rats. Hematoxylin and eosin staining. A lower vascular density is seen in the uterine transplantation (UTx) group. Such decreased vascularization pattern is noticed in both (A) nonimplantation sites and (B) implantation sites. TAC = tacrolimus; L = labyrinth zone; JZ = junctional zone; D = decidual basalis cells; Syn C = syncytiotrophoblast cells; Spo C = spongiotrophoblast cells. Yellow arrows: maternal vascular compartment; black arrows: Fetal capillary space.
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3. Figure 2
Uteri with immunofluorescence staining. (A) Endothelin A and (B) B receptors show a similar distribution pattern between groups, being expressed in both epithelial (epi) and stromal (Str) compartments. DAPI = 4′,6-diamidino-2-phenylindole; TAC = tacrolimus; Tx = uterine transplantation.
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4. Figure 3
Comparison of weight evolution between pups from the different experimental groups and the two breeding colonies. The y-axis presents the weight in grams, and the x-axis presents the age in days. Data are presented for (A) female and (B) male offspring. Abbreviations as in Figure 1.
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5. Supplemental Figure 1
Schematic illustration of the study design. UTx+TAC = allogeneic uterine transplantation and immunosuppression by tacrolimus; Sham+TAC = surgical removal of the left uterine horn and immunosuppression by tacrolimus; Sham = surgical removal of the left uterine horn without any immunosuppressiion; BC = external breeding colony; BC+TAC = external breeding colony and immunosuppression by tacrolimus. All animals under immunosuppression were administered tacrolimus at a dose of 0.4 mg/kg/d for 8 weeks and then 0.2 mg/kg/d until the end of the experiment.
Fertility and Sterility  , e1DOI: ( /j.fertnstert )
Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions