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Dexamethasone regulation of thymic stromal lymphopoietin receptor expression on mast cells and their precursors  Zoulfia Allakhverdi, PhD, Michael R.

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Presentation on theme: "Dexamethasone regulation of thymic stromal lymphopoietin receptor expression on mast cells and their precursors  Zoulfia Allakhverdi, PhD, Michael R."— Presentation transcript:

1 Dexamethasone regulation of thymic stromal lymphopoietin receptor expression on mast cells and their precursors  Zoulfia Allakhverdi, PhD, Michael R. Comeau, BSc, Guy Delespesse, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 2, Pages e2 (February 2011) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 TSLP receptor regulation on CD34+ cells and primary mast cells. CD34+ cells and MCs were prepared as described2,3 and stimulated for 48 hours with suboptimal concentrations of TNF (2.5 ng/mL), IL-1 (1 ng/mL), and dexamethasone (DEX; 10−7 mol/L), as indicated. Representative of 4 experiments. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Dexamethasone (DEX) modulates the response of MCs to TSLP. Primary peripheral blood–derived MCs were activated with optimal concentrations of TNF (25 ng/mL)/IL-1 (10 ng/mL) and TSLP (10 ng/mL) with or without dexamethasone (10−7 mol/L). The productions of IL-5, IL-13, CCL1, and IL-6 were measured after 16 hours of culture. Means + SEMs of 6 experiments. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 TSLP receptor regulation by microbial and TLR ligands on CD34+ cells and mast cells. Staphylococcus aureus Cowan I strain (SAC) (1:5000), peptidoglycan (PGN) (50 μg/mL), LPS (1 μg/mL), flagellin (1 μg/mL), and imiquimod (1 μg/mL) were added to cultures of CD34+ cells and MCs, and 48 hours later, TSLPR expression was detected. Representative of 3 experiments. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Dexamethasone (DEX) modulates the response of CD34+ cells to TSLP
Dexamethasone (DEX) modulates the response of CD34+ cells to TSLP. Umbilical cord blood–derived CD34+ cells were activated with optimal concentrations of TNF (25 ng/mL)/IL-1 (10 ng/mL) and TSLP (10 ng/mL) with or without dexamethasone (10−7 mol/L). The production of IL-5 was measured after 16 hours of culture. Means + SEMs of 6 experiments. ∗P < .05; ∗∗ P < .01. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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