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Optimal Histologic Cutpoints for Treatment Response in Patients With Eosinophilic Esophagitis: Analysis of Data From a Prospective Cohort Study  Craig.

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Presentation on theme: "Optimal Histologic Cutpoints for Treatment Response in Patients With Eosinophilic Esophagitis: Analysis of Data From a Prospective Cohort Study  Craig."— Presentation transcript:

1 Optimal Histologic Cutpoints for Treatment Response in Patients With Eosinophilic Esophagitis: Analysis of Data From a Prospective Cohort Study  Craig C. Reed, W. Asher Wolf, Cary C. Cotton, Spencer Rusin, Irina Perjar, Johnathan Hollyfield, John T. Woosley, Nicholas J. Shaheen, Evan S. Dellon  Clinical Gastroenterology and Hepatology  Volume 16, Issue 2, Pages e2 (February 2018) DOI: /j.cgh Copyright © 2018 AGA Institute Terms and Conditions

2 Figure 1 (A) Endoscopic, symptomatic, and combined response depending on post-treatment eosinophil count thresholds. (B) Endoscopic, symptomatic, and combined response depending on percent change in post-treatment eosinophil counts. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

3 Figure 2 Frequency of baseline esophageal dilation in symptom responders (defined by 50% decrease in VAS), as stratified by histologic response (defined as <15 eos/hpf). rx, treatment. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

4 Figure 3 (A) Predicted probability of symptom response per post-treatment eosinophil count. (B) Predicted probability of endoscopic treatment response per post-treatment eosinophil count. (C) Predicted probability of combined treatment response per post-treatment eosinophil count. (D) Predicted probability of symptom response per percent change in post-treatment eosinophil count. (E) Predicted probability of endoscopic treatment response per percent change in post-treatment eosinophil count. (F) Predicted probability of combined treatment response per percent change in post-treatment eosinophil count. CI, confidence interval. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

5 Supplementary Figure 1 (A) Symptomatic responses per post-treatment eosinophil category. (B) Endoscopic responses per post-treatment eosinophil category. (C) Combined symptomatic and endoscopic responses per post-treatment eosinophil category. (D) AUC values per treatment response using post-treatment eosinophil counts. (E) AUC values per treatment response using 50% change in post-treatment eosinophil count. (F) AUC values per treatment response using 90% change in post-treatment eosinophil count. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions


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