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Volume 49, Issue 4, Pages (April 2006)

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Presentation on theme: "Volume 49, Issue 4, Pages (April 2006)"— Presentation transcript:

1 Volume 49, Issue 4, Pages 666-674 (April 2006)
Pre-Treatment Nomogram for Disease-Specific Survival of Patients with Chemotherapy- Naive Androgen Independent Prostate Cancer  Robert Svatek, Pierre I. Karakiewicz, Michael Shulman, Jose Karam, Paul Perrotte, Elie Benaim  European Urology  Volume 49, Issue 4, Pages (April 2006) DOI: /j.eururo Copyright © 2005 Elsevier B.V. Terms and Conditions

2 Fig. 1 Kaplan-Meier estimates of AIPC-specific survival, overall and other-cause survival with 95% confidence intervals. European Urology  , DOI: ( /j.eururo ) Copyright © 2005 Elsevier B.V. Terms and Conditions

3 Fig. 2 The effect (and its 95% confidence interval) of each predictor on log relative hazard of androgen insensitive prostate cancer-specific survival. All other remaining predictors are held constant. European Urology  , DOI: ( /j.eururo ) Copyright © 2005 Elsevier B.V. Terms and Conditions

4 Fig. 3 Calibration plots for prediction of AIPC-specific survival at 12–60 months. Nomogram data are shown in the left hand column and recursive partitioning data are shown in the right hand column. European Urology  , DOI: ( /j.eururo ) Copyright © 2005 Elsevier B.V. Terms and Conditions

5 Fig. 4 Nomogram predicting AIPC-specific survival.
PSA ADT init.: PSA at start of androgen deprivation therapy ADT: androgen deprivation therapy AIPC: androgen insensitive prostate cancer Time ADT≥AIPC(M): Time from ADT to AIPC diagnosis. 12(M)AIPC-Spec.Surv. – probability of AIPC-specific survival at 12 months after AIPC diagnosis 24(M)AIPC-Spec.Surv – probability of AIPC-specific survival at 24 months after AIPC diagnosis 36(M)AIPC-Spec.Surv – probability of AIPC-specific survival at 36 months after AIPC diagnosis 48(M)AIPC-Spec.Surv – probability of AIPC-specific survival at 48 months after AIPC diagnosis 60(M)AIPC-Spec.Surv – probability of AIPC-specific survival at 60 months after AIPC diagnosis Instruction for physician: Locate the patient’s PSA at the time of androgen-deprivation therapy initiation (PSA at ADT init.) on the PSA at ADT init. axis. Draw a line straight upwards to the Points axis to determine how many points towards AIPC-specific survival the patient receives. Repeat this process for the other predictors, each time drawing a straight upward line to the Points axis. Sum the points for each predictor and locate this sum on the Total Points axis. Draw a line straight down to find the patient’s probability of AIPC-specific survival at 12, 24, 36, 48 and 60 months after androgen insensitive prostate cancer (AIPC) diagnosis, assuming he does not die of another cause first. European Urology  , DOI: ( /j.eururo ) Copyright © 2005 Elsevier B.V. Terms and Conditions


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