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Stimulation on Demand: Closing the Loop on Deep Brain Stimulation

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Presentation on theme: "Stimulation on Demand: Closing the Loop on Deep Brain Stimulation"— Presentation transcript:

1 Stimulation on Demand: Closing the Loop on Deep Brain Stimulation
Fernando J. Santos, Rui M. Costa, Fatuel Tecuapetla  Neuron  Volume 72, Issue 2, Pages (October 2011) DOI: /j.neuron Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Illustration of an Open-Loop and an Adaptive Closed-Loop Deep Brain Stimulation (DBS) Paradigm (A) Standard “open-loop” high-frequency (130 Hz) DBS consists of continuous stimulation of a target structure (i.e., internal segment of the globus pallidum, GPi) through an implanted electrode. (B) Adaptive “closed-loop” DBS consists of using the online activity of a reference structure (i.e., primary motor cortex, M1) as a trigger for stimulation of the target structure (i.e., GPi) after a certain delay (i.e., 80 ms). This results in a lower frequency and more irregular pattern of stimulation and promotes a substantial reduction of Parkinsonian akinesia compared with standard “open-loop” DBS protocols, by adapting the stimulation to the dynamics of cortico-basal ganglia networks. Neuron  , DOI: ( /j.neuron ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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