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Hepatoid Carcinoma of the Lung with Anaplastic Lymphoma Kinase Gene Rearrangement  Sean Khozin, MD, Mark J. Roth, MD, Arun Rajan, MD, Karen Smith, MD,

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Presentation on theme: "Hepatoid Carcinoma of the Lung with Anaplastic Lymphoma Kinase Gene Rearrangement  Sean Khozin, MD, Mark J. Roth, MD, Arun Rajan, MD, Karen Smith, MD,"— Presentation transcript:

1 Hepatoid Carcinoma of the Lung with Anaplastic Lymphoma Kinase Gene Rearrangement 
Sean Khozin, MD, Mark J. Roth, MD, Arun Rajan, MD, Karen Smith, MD, Anish Thomas, MD, Arlene Berman, MS, Giuseppe Giaccone, MD, PhD  Journal of Thoracic Oncology  Volume 7, Issue 11, Pages e29-e31 (November 2012) DOI: /JTO.0b013e a23 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Baseline CT scan showing masses in the (A) anterior chest wall (arrow) and (B) right middle lobe of the lung (arrow). After 2 months of therapy with crizotinib, a restaging CT scan showed (C) more than 30% reduction in the chest-wall mass (arrow), (D) near-complete resolution of the right middle lobe lung mass (arrow), and approximately 20% reduction in the right pleural-based mass (not shown). CT, computed tomography. Journal of Thoracic Oncology 2012 7, e29-e31DOI: ( /JTO.0b013e a23) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 A, Romanowski (200×) and (B) hematoxylin and eosin (400×) staining showing large atypical cells with round-to-oval hyperchromatic nuclei, prominent nucleoli, and moderate-to-abundant dense cytoplasm arranged in trabecular aggregates morphologically, suggestive of hepatic differentiation. C, Immunocytochemical analysis of cellblock section with antibodies to HepPar-1 (400×) demonstrated a positive granular cytoplasmic staining pattern. Journal of Thoracic Oncology 2012 7, e29-e31DOI: ( /JTO.0b013e a23) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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