1. Review from yesterday Non-Specific Defenses Specific Defenses
1st Line:
Skin
Tears, Mucus, Saliva
Sweat
2nd Line:
Inflammatory Response
Fever
Against Viruses:
Interferon
Specific Defenses
Humoral Immunity
B-Cells
Antibodies
Cell-Mediated Immunity…

2. Specific Defenses Cell-Mediated Immunity Killer T Cells: The HIT MAN!
Kills infected Body cells

3. Cell-Mediated Immune Response “Calling out the hitman – Killer T!”
Pacman the boss eats pathogen and finds ID
T cell binds to activated macrophage to read the antigen
Helper T Cell tells Killer T cell who to look for
Killer T Cell checks ID
Helper T Cell “the hitman” picks up ID
If ID matches, Killer T eliminate the bacteria
Antigens are displayed on surface of macrophage
Killer T cells bind to infected cells, disrupting their cell membranes and destroying them

5. Cell-Mediated Immunity: Worksheet
Pathogen enters body
Macrophage eats pathogen
Displays Antigen on its surface
Helper T cell gets antigen ID from Macrophage
Helper T cell tells Killer T cells what antigen to look for
Killer T cells kill any cell displaying antigen (including infected body cells)
Cell dies
Suppressor T cells tell Killer T cells to stop killing when pathogen is gone

6. Acquired Immunity

7. Acquired Immunity 2 Kinds: Active Immunity Passive Immunity
You make antibodies
Passive Immunity
Another person or thing’s antibodies are put into your body

8. Active Immunity
When immunity comes from your body making antibodies for a pathogen.
Once the antibodies are present, you will not get sick from that pathogen again.
Permanent Immunity

9. Active Immunity 2 ways to get Active Immunity Get sick, get antibodies
Vaccination
Purposefully introduce a weakened pathogen into your body
You do not get sick
Your body makes antibodies for that pathogen

10. Passive Immunity
When immunity comes from someone or something else’s antibodies being introduced into the body
Provides TEMPORARY immunity
Your body will eventually destroy the foreign antibodies.

11. Passive Immunity Get a shot of antibodies (vaccine)
before traveling to a foreign country for a short period of time.
After Rabies exposure
Mothers give their antibodies to baby through breast milk

12. In Review 2 types of Acquired Immunity Active Passive
Your body makes antibodies
Get sick
Get vaccine of weakened pathogen
PERMANENT
Passive
Put someone/thing else’s antibodies into your body
Mother’s breastmilk to baby
Vaccine of antibodies
TEMPORARY