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Volume 125, Issue 5, Pages 1311-1319 (November 2003)
Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis Thomas Ullman, Victoria Croog, Noam Harpaz, David Sachar, Steven Itzkowitz Gastroenterology Volume 125, Issue 5, Pages (November 2003) DOI: /j.gastro
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Figure 1 Flowchart of outcomes of patients who underwent colectomy within 6 months of fLGD. Squares indicate colonoscopic findings; circles indicate colectomy findings. UC, ulcerative colitis; LGD, low-grade dysplasia; HGD, high-grade dysplasia; No D, no dysplasia; CA I, stage I adenocarcinoma; f/u, follow-up. Gastroenterology , DOI: ( /j.gastro )
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Figure 2 Flowchart of outcomes for patients who did not undergo colectomy within 6 months of initial fLGD. Squares indicate the worst surveillance colonoscopy result; circles indicate colectomy results. UC, ulcerative colitis; LGD, low-grade dysplasia; HGD, high-grade dysplasia; No D, no dysplasia; CA I, stage I adenocarcinoma; CA II, stage II adenocarcinoma; CA III, stage III adenocarcinoma; OvCA, ovarian carcinoma; f/u, follow-up. Items in squares represent the worst colonoscopic finding before colectomy. Items in circles represent worst histopathology in the colectomy specimen. Gastroenterology , DOI: ( /j.gastro )
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Figure 3 Timelines of colonoscopic and surgical follow-up after fLGD in patients who underwent colectomy with progression to CRC (A), progression to HGD (B), or no progression beyond LGD (C). −, no dysplasia; I, indefinite dysplasia; L, low-grade dysplasia; H, high-grade dysplasia; CA, carcinoma; #, ovarian CA. Each bar represents 1 patient. Each symbol within a bar represents the worst histological finding at a given colonoscopy, and the notation at the end of each bar represents the stage of cancer or final pathology at colectomy. Bars with dashed outlines indicate patients with multifocal fLGD. Gastroenterology , DOI: ( /j.gastro )
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Figure 4 Timeline of colonoscopic follow-up after fLGD of patients who did not go to colectomy. −, no dysplasia; I, indefinite dysplasia; L, low-grade dysplasia; P, polypoid LGD; H, high-grade dysplasia. Each bar represents 1 patient. Each symbol within a bar represents the worst histological finding at a given colonoscopy, and the bar ends at the time of the last documented colonoscopy. Bars with dashed outlines indicate patients with multifocal fLGD. Gastroenterology , DOI: ( /j.gastro )
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Figure 5 Kaplan-Meier curve comparing the cumulative progression to advanced neoplasia in patients with any fLGD (solid line), unifocal fLGD (dashed line), and multifocal fLGD (dotted line). Cross-hatches (+) indicate censoring of patients for no further follow-up or colectomy without evidence of progression. Vertical lines (|) represent progression events. Gastroenterology , DOI: ( /j.gastro )
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