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A. Oliver, A. Mena  Clinical Microbiology and Infection 

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Presentation on theme: "A. Oliver, A. Mena  Clinical Microbiology and Infection "— Presentation transcript:

1 Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistance 
A. Oliver, A. Mena  Clinical Microbiology and Infection  Volume 16, Issue 7, Pages (July 2010) DOI: /j x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Percentages of mutators and non-mutators among cystic fibrosis isolates showing a growing number of mutations in 34 genes, as described by Mena et al. [13]. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Schematic representation of the evolution (adaptation) of Pseudomonas aeruginosa during cystic fibrosis chronic lung infection and the role of mutators as catalyzers of the process. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

4 FIG. 3 Percentages of cystic fibrosis (CF) mice showing Pseudomonas aeruginosa-positive cultures in which PAOΔmutS outcompetes PAO1 (Competition Index, CI > 1) over time, as described by Mena et al. [85]. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions


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