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Intensified Mycophenolate Mofetil Dosing and Higher Mycophenolic Acid Trough Levels Reduce Severe Acute Graft-versus-Host Disease after Double-Unit Cord.

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Presentation on theme: "Intensified Mycophenolate Mofetil Dosing and Higher Mycophenolic Acid Trough Levels Reduce Severe Acute Graft-versus-Host Disease after Double-Unit Cord."— Presentation transcript:

1 Intensified Mycophenolate Mofetil Dosing and Higher Mycophenolic Acid Trough Levels Reduce Severe Acute Graft-versus-Host Disease after Double-Unit Cord Blood Transplantation  Stephen Harnicar, Doris M. Ponce, Patrick Hilden, Junting Zheng, Sean M. Devlin, Marissa Lubin, Melissa Pozotrigo, Sherry Mathew, Nelly Adel, Nancy A. Kernan, Richard O'Reilly, Susan Prockop, Andromachi Scaradavou, Alan Hanash, Robert Jenq, Marcel van den Brink, Sergio Giralt, Miguel A. Perales, James W. Young, Juliet N. Barker  Biology of Blood and Marrow Transplantation  Volume 21, Issue 5, Pages (May 2015) DOI: /j.bbmt Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 (A) Cumulative incidence of day 100 II to IV aGVHD by MPA trough level (n = 83). In a day 14 landmark analysis, mean week 1 and 2 MPA trough levels ≥ .5 μg/mL had no association with grades II to IV aGVHD by day 100. (B) Cumulative incidence of day 100 III and IV aGVHD by MPA trough level (n = 83). In a day 14 landmark analysis, the incidence of grade III and IV aGVHD at day 100 was lower in dCBT recipients with mean week 1 and 2 MPA trough levels ≥ .5 μg/mL. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions


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