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The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study  F. Pan, L. Blizzard, J.

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Presentation on theme: "The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study  F. Pan, L. Blizzard, J."— Presentation transcript:

1 The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study  F. Pan, L. Blizzard, J. Tian, F. Cicuttini, T. Winzenberg, C. Ding, G. Jones  Osteoarthritis and Cartilage  Volume 25, Issue 2, Pages (February 2017) DOI: /j.joca Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Concurrent associations between category of body mass index and prevalence of medial tibiofemoral cartilage defects at each phase in (A) offspring; (B) controls. The bars represent prevalence of medial tibiofemoral cartilage defects in normal, overweight and obese group (Normal: body mass index < 25; Overweight: 25 ≤ body mass index < 30; Obesity: body mass index ≥ 30). P for trend determined by Kruskal–Wallis test. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Interaction between weight and time on lateral knee cartilage volume in offspring. There was a significant interaction between weight and time on lateral knee cartilage volume. The effect of increasing weight on lateral knee cartilage volume becomes more negative over time. The model adjusted for common covariates including age, sex, height, smoking, knee injury, radiographic knee OA, bone size and cartilage defects. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

4 Fig. S1Increase in medial tibiofemoral cartilage defects among those with weight loss, weight stable and weight gain over 10 years. An increase in medial tibiofemoral cartilage defect was defined as an increase of one or greater. Weight loss, weight stable and weight gain were defined as those who lost relative weight change of 5% or greater, those who gained or lost less 5% and those who gained 5%. P for trend determined by Kruskal–Wallis test. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions


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