1. NMP22® BladderChek® Test Case Studies

2. Value of a False Positive Test Result: Case Study #2 Diagnosis: 68 year old male non-smoker Presenting symptom: Hematuria Cystoscopy: Benign / Suspicious Cytology: Atypical / Suspicious NMP22 BladderChek: Positive Pathology: TCC T2aG3 1,331 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 293:810-816 (2005) Data on file at Matritech

3. Value of a False Positive Test Result: Case Study #3 Diagnosis: 68 year old male with H/O smoking Presenting symptom: Hematuria Cystoscopy: No abnormality Cytology:Malignant Cells NMP22 BladderChek: Positive Upper tract imaging T2G2 Ca of ureter Nephroureterectomy 1,331 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 293:810-816 (2005) Data on file at Matritech

4. Value of a False Positive Test Result: Case Study #1 Monitoring: 80 yr. old male 1993 Initial diagnosis: TCC Immunotherapy 2/14/02 – Cystoscopy: tumor / benign – Cytology: Suspicious / Atypical – NMP22 BladderChek: Positive Pathology: TCC Ta G2 668 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 295:299-305 (2006) Data on file at Matritech

5. Value of a False Negative Test Result: Case Study #1 Monitoring : 65 yr old male 2000 Initial diagnosis T1 9/2001 Immunotherapy 12/2001 – Cystoscopy: tumor-like growth – Cytology: Atypical – NMP22 BladderChek: Negative Pathology: benign disease / urethritis 668 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 295:299-305 (2006) Data on file at Matritech

6. Added Value when Cytology is Uninformative Case Study #1 Monitoring: 77 yr old male 1997 Initial diagnosis: TCC Ta Sep 2001 Immunotherapy Oct 2001 – Cystoscopy: tumor / cis – Cytology: Suspicious – NMP22 BladderChek: Positive Pathology: TCC T1 G3 668 patient, 23 site Clinical Study published in Grossman HB, et al. JAMA 295:299-305 (2006) Data on file at Matritech