1. Volume 153, Issue 4, Pages 898-900 (October 2017)
Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut 
Sebastian Zundler, Anika Klingberg, Daniela Schillinger, Sarah Fischer, Clemens Neufert, Imke Atreya, Matthias Gunzer, Markus F. Neurath 
Gastroenterology 
Volume 153, Issue 4, Pages (October 2017)
DOI: /j.gastro
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2. Figure 1
(A) Representative 3D-reconstruction of LSFM-acquired data. Human IBD T cells are shown in green, murine vessels in red and autofluorescent tissue in grey. (B) Blend and maximum intensity projection (MIP) reconstruction accentuating vessel anatomy and transferred cells, respectively. (C) High magnification of vessels in ileal villi (red) and homed IBD T cells (green). (D) Beam path of LSFM. Confer video for details. Image provided by LaVision Biotec. (E) Volume-based quantification of cells. Scale bars – 100μm (A), 1000μm (B), 50μm (C), 200μm (E).
Gastroenterology  , DOI: ( /j.gastro )
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3. Figure 2
Analysis of homing in a humanized mouse model of T-cell trafficking to the inflamed gut in vivo. CD4+ T cells from a patient with UC were treated as indicated and injected to colitic immunodeficient mice. Homed cells were quantified in three random positions. Scale bars – 500μm (left, middle), 150μm (right). ***P < .001.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2017 AGA Institute Terms and Conditions