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Volume 1, Issue 3, Pages 163-165 (May 2015)
Lichen sclerosus on the penis associated with striking elastic fibers accumulation (nevus elasticus) and differentiated penile intraepithelial neoplasia progressing to invasive squamous cell carcinoma Denisa Kacerovska, MD, PhD, Michal Michal, MD, Milan Hora, MD, PhD, Ladislav Hadravsky, MD, Dmitry V. Kazakov, MD, PhD JAAD Case Reports Volume 1, Issue 3, Pages (May 2015) DOI: /j.jdcr Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 1 A flat, red-colored patch with irregular and poorly defined margins on the glans penis. The surrounding skin showed a whitish hue. JAAD Case Reports 2015 1, DOI: ( /j.jdcr ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 2 A, The epidermis showed focally mild hyperplastic areas with atypical keratinocytes in the basal cell layer compatible with differentiated PeIN. B, In several specimens, full-thickness atypia corresponding to carcinoma in situ and foci of invasive squamous cell carcinoma were found. (Hematoxylin-eosin stain.) JAAD Case Reports 2015 1, DOI: ( /j.jdcr ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 3 A, In the mid and reticular dermis, there were striking areas of pink condensed finely fibrillary and wavy elastic material. (Hematoxylin-eosin stain.) B, Histochemical staining for elastic stain showed a massive increase in elastic fibers in the mid and reticular dermis contrasted strikingly to their near absence in the superficial subepithelial tissues. Elastic stains also showed increased presence of elastic fibers around blood vessels in the reticular portion of the dermis. JAAD Case Reports 2015 1, DOI: ( /j.jdcr ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions
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