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Lizbeth R.A. Intong, MD, Dédée F. Murrell, MA, BMBCh, MD 

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Presentation on theme: "Lizbeth R.A. Intong, MD, Dédée F. Murrell, MA, BMBCh, MD "— Presentation transcript:

1 Inherited epidermolysis bullosa: New diagnostic criteria and classification 
Lizbeth R.A. Intong, MD, Dédée F. Murrell, MA, BMBCh, MD  Clinics in Dermatology  Volume 30, Issue 1, Pages (January 2012) DOI: /j.clindermatol Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Fig. 1 Basement membrane zone (BMZ) ultrastructure and target proteins. (Adapted with permission from Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

3 Fig. 2 Blisters on the feet of a patient with epidermolysis bullosa simplex-localized. Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

4 Fig. 3 Herpetiform blisters on a baby with epidermolysis bullosa simplex-Dowling-Meara. Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

5 Fig. 4 A baby with junctional epidermolysis bullosa-Herlitz type with extensive blistering. The baby died soon after birth. Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

6 Fig. 5 Loss of nails is seen in this adult with junctional epidermolysis bullosa-generalized other. Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

7 Fig. 6 Enamel defects in junctional epidermolysis bullosa-generalized other. (Courtesy of Dr Richard Widmer, University of Sydney School of Dentistry, Sydney, NSW, Australia.) Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

8 Fig. 7 A patient with dominant dystrophic epidermolysis bullosa-generalized with scarring on her legs. Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

9 Fig. 8 A, A patient with recessive dystrophic epidermolysis bullosa-generalized severe (RDEB-GS) with severe pseudosyndactyly of the feet. (Reprinted with permission from MD Thesis, UNSW 2006 by Dedee F Murrell, Studies in Blistering Disorders.) B, A patient with RDEB-generalized severe shows severe, generalized blistering on the trunk. Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

10 Fig. 9 Recessive dystrophic epidermolysis bullosa-generalized other with a lesser degree of pseudosyndactyly. (Reprinted with permission from MD Thesis, UNSW 2006 by Dedee F Murrell, Studies in Blistering Disorders.) Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions

11 Fig. 10 A child with Kindler syndrome showing (A) poikiloderma on the chest and (B) atrophy of the dorsal hands with dystrophic nails. (Courtesy of Dr Maureen Rogers, Sydney, NSW, Australia.) Clinics in Dermatology  , 70-77DOI: ( /j.clindermatol ) Copyright © 2012 Elsevier Inc. Terms and Conditions


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