1. DNA Replication/ Regeneration

2. Goal of DNA Replication
Makes an _________ copy of itself
(Needed for new cells produced during Mitosis)

3. Goal of DNA Replication
Why do we need new cells?
_________
Repair & _________
REGENERATION

4. Regeneration Regeneration of a lost limb
1. De-differentiation of adult cells to stem cells
2. Development of stem cells into new tissue

5. When does it take place?
Regeneration/ Replication of new _________ takes place during the _________ cycle
S Phase of _________ (Mitosis)

6. The Process of DNA Replication
1. _________
2. _________
3. _________
4. _________________
5. _________

7. Step 1: _________ Enzyme: _________ strand uncoils
DNA _________ unwinds it

8. Step 2: Unzipping DNA strands breaks in half (unzips)
_________ bonds are broken
Enzyme: DNA helicase breaks _________ bonds

9. “Y” formation known as replication fork
Step 2: continued
“Y” formation known as replication fork

10. Step 3: Adding New Parts
Enzyme: DNA _________ matches original DNA strand with complementary base pairs using free nucleotides

11. Step 3: Adding New Parts

12. Step 3: Adding New Parts Proofreading
Enzyme: DNA Polymerase can “backtrack” and _________ any mistakes that are made
DNA polymerase will make a mistake about 1 out of every _________ free nucleotides it matches

13. Step 4: Two DNA molecules
Final product: 2 _________ DNA strands
One set of DNA for each cell

14. Step 5: Recoil
DNA strand winds back up into a _________ _________

15. DNA Replication
Entire chromosome can be replicated in about 8 hours

16. The Future of DNA Replication/ Regeneration
Humans capable of regenerating nerve cells (cure paralysis)?
Regenerating new skin cells (slow the aging process)?
Humans capable of
regenerating lost limbs
(combining lizard DNA
with humans)?
Dr. Connors