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New ELN Recommendations

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Presentation on theme: "New ELN Recommendations"— Presentation transcript:

1 New ELN Recommendations

2

3 2017 ELN Guidelines: Overview

4 2016 Updated WHO Classification of AML

5 Molecular Landscape of AML

6 Molecular Classification of AML: Implications for Diagnosis

7 Diagnostic Workup of AML: Practical Considerations

8 Risk Stratification and Treatment Selection

9 Indications for Allogeneic Transplantation

10 Targeted Therapies for AML: Targeting FLT3

11 Targeted Therapies for AML: Targeting IDH2

12 Measurable/Minimal Residual Disease

13 Using MRD During Treatment to Assess Early Response

14 Using MRD After Treatment to Detect Early Relapse: Example From APL

15 Using MRD After Treatment to Detect Early Relapse: Example From CBF-AML

16 Prognostic Significance of FLT3-ITD Mutation vs MRD Status

17 Using MRD Status to Guide Treatment Selection

18 Prognostic Significance of Age vs Comorbidities/Performance Status

19 Selecting a Non-Intensive Treatment Approach

20 Assessing Response to Hypomethylating Agents

21 Azacitidine in Older Patients With AML 30+: AZA-AML-001 Phase 3 Trial

22 Outcomes With Azacitidine in Patients Who Do Not Achieve CR: AZA-AML-001

23 Managing Toxicities Associated With Hypomethylating Agents

24 Decitabine in Older Patients With AML: DACO-016 Phase 3 Trial

25 Outcomes With Decitabine in Patients With Baseline Hyperleukocytosis: DACO-016

26 Conclusions

27 Abbreviations

28 Abbreviations (cont)

29 Abbreviations (cont)


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