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David J. Effeney, M.B., F.R.A.C.S.  Journal of Vascular Surgery 

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Presentation on theme: "David J. Effeney, M.B., F.R.A.C.S.  Journal of Vascular Surgery "— Presentation transcript:

1 Prostacyclin production by the heart: Effect of nicotine and carbon monoxide 
David J. Effeney, M.B., F.R.A.C.S.  Journal of Vascular Surgery  Volume 5, Issue 2, Pages (February 1987) DOI: / (87) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Infusion system. Swivel is housed in a rubber stopper. Connection between swivel and catheter is made by an intravenous giving set-injection site connected to 18-gauge blunt needle. Dental bands and stiff copper wire are used to keep the components approximated. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Inhibition of adenosine diphosphate (ADP)—induced platelet aggregation by PGI2-like substance produced by 100 mg of left ventricle. The x axis is time in minutes and the y axis is change in light transmission (ΔT) in arbitrary units. Thick arrows mark time of addition of 50 μl of incubation solution or Tris-arachidonic acid mixture. Thin arrows mark time of addition of ADP. Note partial inhibition of ADP-induced aggregation. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Inhibition of adenosine diphosphate (ADP)—induced platelet aggregation by PGI2-like substance produced by 100 mg of left atrium. The x axis is time in minutes and the y axis is change in light transmission (ΔT) in arbitrary units. Thick arrows mark time of addition of 50 μl of incubation solution of Tris-arachidonic acid mixture. Thin arrows mark time of addition of ADP. Note complete inhibition of ADP-induced aggregation. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions


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