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Therapeutic angiogenesis induced by local autologous bone marrow cell implantation  Kimikazu Hamano, MD, Tao-Sheng Li, MD, Toshiro Kobayashi, MD, Ken Hirata,

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Presentation on theme: "Therapeutic angiogenesis induced by local autologous bone marrow cell implantation  Kimikazu Hamano, MD, Tao-Sheng Li, MD, Toshiro Kobayashi, MD, Ken Hirata,"— Presentation transcript:

1 Therapeutic angiogenesis induced by local autologous bone marrow cell implantation 
Kimikazu Hamano, MD, Tao-Sheng Li, MD, Toshiro Kobayashi, MD, Ken Hirata, MD, Masafumi Yano, MD, Michihiro Kohno, MD, Masunori Matsuzaki, MD  The Annals of Thoracic Surgery  Volume 73, Issue 4, Pages (April 2002) DOI: /S (02)

2 Fig 1 Experimental canine chronic coronary occlusion model (A) and the schedule of treatments (B). The canine chronic coronary occlusion model was made by ligating the left anterior descending artery (LAD) and all the diagonal branches and distal sites of the oblique marginal branches. Shown are (a) the attached positions of a single crystal in the normal area, (b) the marginal area, and (c) the infarction area. Black dots indicate the injection sites of bone marrow implantation. (Cx = circumflex artery; BMCs = bone marrow cells; PBS = phosphate-buffered saline; %WT = percent wall thickening; Echo = echocardiography.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

3 Fig 2 Changes in local cardiac wall motion in the normal area (left), the marginal area (middle), and the infarction area (right) after bone marrow cell implantation. Representative recording of wall thickening measured by ultrasonic transducer (upper and middle panel). The percent wall thickening (lower panel) was calculated by systolic thickening divided by end-diastolic thickness. In the marginal area, the percent wall thickening was significantly greater in the BMCI group than in the PBS group. (BMCI = bone marrow cell implantation group; PBS = phosphate-buffered saline injection group; Pre = before injection; Post = 30 days after injection, %WT = percent wall thickening.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

4 Fig 3 Immunohistochemical staining with canine anti-CD34 in (A) the phosphate-buffered saline injection (PBS) group and (B) the bone marrow cell implantation (BMCI) group in the marginal area. (C) Quantitative analysis of the microvessel density in each area showed that the density of microvessels in the marginal area was significantly higher in the BMCI group than in the PBS group. The Annals of Thoracic Surgery  , DOI: ( /S (02) )

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