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Biodegradable polymer coating promotes the epithelization of tissue-engineered airway prostheses  Toshihiko Sato, MD, Masato Araki, MD, Naoki Nakajima,

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Presentation on theme: "Biodegradable polymer coating promotes the epithelization of tissue-engineered airway prostheses  Toshihiko Sato, MD, Masato Araki, MD, Naoki Nakajima,"— Presentation transcript:

1 Biodegradable polymer coating promotes the epithelization of tissue-engineered airway prostheses 
Toshihiko Sato, MD, Masato Araki, MD, Naoki Nakajima, PhD, Koichi Omori, MD, Tatsuo Nakamura, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 139, Issue 1, Pages (January 2010) DOI: /j.jtcvs Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 A, The bulk structure of the prosthesis framework: a mesh cylinder reinforced with 5 rings of polypropylene string. B, Cross-sectional schema of the prosthesis conjugated with a collagen layer. The L-lactic acid-co-ε-caprolactam (L–C copolymer) layer is colored blue. The Journal of Thoracic and Cardiovascular Surgery  , 26-31DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Periodical bronchoscopic views of the replaced portion after tracheal replacement. At day 0, the replaced portion can be identified by the blue-colored copolymer layer. At day 7, the copolymer coating remained. At day 14, regenerated reddish tissue could be observed, and the copolymer coating had apparently disappeared. At day 21, the luminal surface was covered with whitish tissue. At day 30, the luminal surface was completely covered with a smooth epithelium. At day 180, neomucosae with regenerated blood vessels were observed (arrows). The Journal of Thoracic and Cardiovascular Surgery  , 26-31DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 A, Macroscopic view of the luminal surface of the prosthesis 18 months after implantation. The arrow shows the regenerated part. The luminal surface is covered with apparently normal mucosa. B, Microscopic examination of a longitudinal section of the regenerated tissue 18 months after prosthesis implantation. The regenerated neomucosa with an epithelial lining is observed on the prosthesis. (Hematoxylin and eosin staining, magnification 10×.) C, Ciliated columnar epithelial cells have grown over the prosthesis, whereas the center of the prosthesis is not as dense as in the peripheral regions. (Hematoxylin and eosin staining, magnification 40×.) L, Bronchial lumen; P, polypropylene mesh. The Journal of Thoracic and Cardiovascular Surgery  , 26-31DOI: ( /j.jtcvs ) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

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