Presentation is loading. Please wait.

Presentation is loading. Please wait.

Immune factors in breast milk related to infant milk allergy are independent of maternal atopy  Kirsi M. Järvinen, MD, PhD, Mayte Suárez-Fariñas, PhD,

Published byBeverly Knight Modified over 5 years ago

Similar presentations

Presentation on theme: "Immune factors in breast milk related to infant milk allergy are independent of maternal atopy  Kirsi M. Järvinen, MD, PhD, Mayte Suárez-Fariñas, PhD,"— Presentation transcript:

1 Immune factors in breast milk related to infant milk allergy are independent of maternal atopy 
Kirsi M. Järvinen, MD, PhD, Mayte Suárez-Fariñas, PhD, Erkki Savilahti, MD, PhD, Hugh A. Sampson, MD, M. Cecilia Berin, PhD  Journal of Allergy and Clinical Immunology  Volume 135, Issue 5, Pages e6 (May 2015) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Human milk immune markers that were different between mothers with a CMA infant and those with a non-CMA infant. A, IL-1β. B, IL-6. C, IL-10. D, TSLP (t test, shown after logarithmic transformation). E, Multivariate score combining all 4 cytokines A-D (multivariate U-statistics). On the box plots' horizontal line, median; box, 25th to 75th percentile; whiskers, 5th to 95th percentile; round symbol, geometric mean. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A, Hierarchical cluster analysis of human milk immune factors using Spearman correlation and average agglomeration algorithm. Correlation coefficient associated color coding shown; *P < .05, **P < .01, ***P < P values (as %) in blue in the resultant dendrogram indicate the degree of stability of each cluster. Height of ≤0.4 indicates clusters of significant correlation. Clusters C1, C2, and C3, and subclusters (a-d) were identified. B, Multivariate μ score combining all markers in the cluster (multivariate U-statistics). Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Spearman rank correlation of human milk factors, including cytokines, chemokines, growth factors, specific IgA, leukocyte proportion, age of baby (ie, duration of lactation), and age of mother. Shown are the correlation coefficient and color coding corresponding to values between −1.0 and 1.0, indicating negative and positive correlation, respectively. *P < .05, **P < .01, ***P < BLG, Beta-lactoglobulin; CS, casein; ECP, eosinophil cationic protein; eos, eosinophil; gran, granulocyte; lymf, lymphocyte; mf, macrophage/secretory epithelial cell; mono, monocyte; neutr, neutrophil. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Classification and regression tree with input from human milk levels of cytokines, chemokines, growth factors, specific IgA, and maternal demographics. This model correctly classified CMA outcome in 80% of the samples. Numbers in blue indicate healthy infants, and numbers in red indicate CMA infants. There are 15 misclassified patients: 9 healthy subjects were misclassified as CMA (7+2+0; see the blue numbers arriving to the red nodes), and 6 CMA patients were misclassified as healthy (0+1+5; see red numbers arriving to the blue nodes). Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Immune factors in breast milk related to infant milk allergy are independent of maternal atopy  Kirsi M. Järvinen, MD, PhD, Mayte Suárez-Fariñas, PhD,"

Similar presentations

Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,
Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy  Scott.

Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy  Scott.
Multiple-checkpoint inhibition of thymic stromal lymphopoietin–induced TH2 response by TH17-related cytokines  Sofia I. Bogiatzi, BSc, Maude Guillot-Delost,

Multiple-checkpoint inhibition of thymic stromal lymphopoietin–induced TH2 response by TH17-related cytokines  Sofia I. Bogiatzi, BSc, Maude Guillot-Delost,
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O
Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,
Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma  Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma  Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,
Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes  Annette T. Hastie, PhD, Wendy C. Moore,

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes  Annette T. Hastie, PhD, Wendy C. Moore,
Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy  Michael Kulis, PhD, Katie.

Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy  Michael Kulis, PhD, Katie.
RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications  Mayte.

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications  Mayte.
Asthma inflammatory phenotypes show differential microRNA expression in sputum  Tania Maes, PhD, Francisco Avila Cobos, MSc, Florence Schleich, MD, PhD,

Asthma inflammatory phenotypes show differential microRNA expression in sputum  Tania Maes, PhD, Francisco Avila Cobos, MSc, Florence Schleich, MD, PhD,
An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis  Amy S. Paller, MD, MS, Yael Renert-Yuval, MD, Maria Suprun, MPH,

An IL-17–dominant immune profile is shared across the major orphan forms of ichthyosis  Amy S. Paller, MD, MS, Yael Renert-Yuval, MD, Maria Suprun, MPH,
Reduced TH1/TH17 CD4 T-cell numbers are associated with impaired purified protein derivative–specific cytokine responses in patients with HIV-1 infection 

Reduced TH1/TH17 CD4 T-cell numbers are associated with impaired purified protein derivative–specific cytokine responses in patients with HIV-1 infection 
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,
Season of birth shapes neonatal immune function

Season of birth shapes neonatal immune function
Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes  Emma M. Savilahti, MD, Ville.

Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes  Emma M. Savilahti, MD, Ville.
Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy  Julie Wang, MD,

Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy  Julie Wang, MD,
Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 
Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy  Pamela A. Frischmeyer-Guerrerio, MD,

Mechanistic correlates of clinical responses to omalizumab in the setting of oral immunotherapy for milk allergy  Pamela A. Frischmeyer-Guerrerio, MD,

Similar presentations

Ads by Google