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Detection of Activated, TIMP-free MMPs

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Presentation on theme: "Detection of Activated, TIMP-free MMPs"— Presentation transcript:

1 Detection of Activated, TIMP-free MMPs
Stanley Zucker, Jian Cao  Chemistry & Biology  Volume 13, Issue 4, Pages (April 2006) DOI: /j.chembiol Copyright © 2006 Elsevier Ltd Terms and Conditions

2 Figure 1 Cartoon Describing the Competition between Exogenous MMP Inhibitor-Tethered Resin Binding and Endogenous TIMP Binding of Activated MMP-2 in the Extracellular Space Following propeptide cleavage, the catalytic site of MMP-2 is exposed and capable of binding to inhibitors. For simplicity, the triplex formed on the cell surface consisting of MT1-MMP, TIMP-2, and proMMP-2 leading to generation of activated MMP-2 is omitted. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2006 Elsevier Ltd Terms and Conditions

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