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Volume 63, Issue 3, Pages (March 2003)

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1 Volume 63, Issue 3, Pages 1094-1103 (March 2003)
Effects of combined ACE inhibitor and angiotensin II antagonist treatment in human chronic nephropathies  Ruth Campbell, Fabio Sangalli, Elena Perticucci, Claudio Aros, Cecilia Viscarra, Annalisa Perna, Andrea Remuzzi, Federico Bertocchi, Luca Fagiani, Giuseppe Remuzzi, Piero Ruggenenti  Kidney International  Volume 63, Issue 3, Pages (March 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions

2 Figure 1 Study design. Patients were randomized to six treatment sequences. Each sequence included four patients. Abbreviations: ACEi, angiotensin-converting enzyme inhibitor; ARA, angiotensin receptor antagonist. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

3 Figure 2 Percent changes from baseline for 24-hour urinary protein excretion rate, mean arterial pressure (MAP) and creatinine clearance. With Bonferroni adjustment, the level of statistical significance is P < Data are mean ± SEM. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

4 Figure 3 Percent changes from baseline for glomerular filtration rate (GFR), effective renal plasma flow (ERPF), filtration fraction (FF), and renal vascular resistances (RVR). With Bonferroni adjustment, the level of statistical significance is P < Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

5 Figure 4 Fractional clearances of neutral dextrans at baseline and at the end of the treatment periods with valsartan, benazepril, and benazepril and valsartan. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions


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