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Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: The Aggressive Cholesterol Therapy to Inhibit Vein Graft.

Published byJulie Little Modified over 6 years ago

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Presentation on theme: "Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: The Aggressive Cholesterol Therapy to Inhibit Vein Graft."— Presentation transcript:

1 Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: The Aggressive Cholesterol Therapy to Inhibit Vein Graft Events randomized clinical trial  Alexander Kulik, MD, MPH, Amy M. Abreu, MPA, BSN, RN, CCRC, Viviana Boronat, MD, MBA, CCRP, Marc Ruel, MD, MPH  The Journal of Thoracic and Cardiovascular Surgery  Volume 157, Issue 1, Pages e1 (January 2019) DOI: /j.jtcvs Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Study enrollment and follow-up. CK, Creatine kinase; CT, computed tomography; MACE, major adverse cardiovascular event. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Low-density lipoprotein (LDL) levels during study enrollment. LDL levels significantly declined for patients who received 80 mg atorvastatin compared with those who received 10 mg atorvastatin (analysis of variance P < .0001). *P = .56 at baseline preoperative measurement. †P <  for measurements at 3 months, 6 months, 9 months, and 12 months. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Vein graft stenosis or occlusion (intention-to-treat analysis). There was no significant difference in the incidence of vein graft occlusion (P = .85) or the combination of vein graft stenosis and occlusion (P = .49) between the 2 groups. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

5 Atorvastatin 80 mg did not significantly reduce the incidence of vein graft disease.
The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

6 Video 1 The lead author explaining the study and the importance of the article. Video available at: The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

7 The Journal of Thoracic and Cardiovascular Surgery 2019 157, 151-161
The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

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