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Delineation of HER2 Gene Status in Breast Carcinoma by Silver in Situ Hybridization is Reproducible among Laboratories and Pathologists  Antonino Carbone,

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Presentation on theme: "Delineation of HER2 Gene Status in Breast Carcinoma by Silver in Situ Hybridization is Reproducible among Laboratories and Pathologists  Antonino Carbone,"— Presentation transcript:

1 Delineation of HER2 Gene Status in Breast Carcinoma by Silver in Situ Hybridization is Reproducible among Laboratories and Pathologists  Antonino Carbone, Gerardo Botti, Annunziata Gloghini, Gianni Simone, Mauro Truini, Maria Pia Curcio, Patrizia Gasparini, Anita Mangia, Tiziana Perin, Sandra Salvi, Adele Testi, Paolo Verderio  The Journal of Molecular Diagnostics  Volume 10, Issue 6, Pages (November 2008) DOI: /jmoldx Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

2 Figure 1 A and B: This case is equivocal for SISH HER2 gene amplification. Note that chromosome 17 is polysomic. A: In the nuclei there are two or more copies of chromosome 17. The corresponding FISH and CISH results were equivocal (not shown). The Journal of Molecular Diagnostics  , DOI: ( /jmoldx ) Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

3 Figure 2 The figure shows a typical example of an amplified case as demonstrated by SISH. A: Less than 3 chromosome 17 signals in tumors cells can be seen. B: same case, HER2. Clusters of HER2 signals in tumor cells are recognizable. The Journal of Molecular Diagnostics  , DOI: ( /jmoldx ) Copyright © 2008 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

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