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Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in.

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Presentation on theme: "Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in."— Presentation transcript:

1 Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in Singapore  Anand Kumar Andiappan, BTech, De Yun Wang, MD, PhD, Ramani Anantharaman, PhD, Bani Kaur Suri, MSc, Bernett Teck Kwong Lee, PhD, Olaf Rotzschke, PhD, Jianjun Liu, PhD, Fook Tim Chew, PhD  Journal of Allergy and Clinical Immunology  Volume 131, Issue 5, Pages e8 (May 2013) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig E1 Regulatory activity in the chromosome 11q13.5 locus containing the GWAS-reported SNPs rs ,E4 rs ,E5 and rs E6 From the UCSC genome browser, we could identify regulatory elements in this 35-kb locus with high reported enhancer activity, as shown by active histone marks, such as H3K27ac and H3K4me1, although not for H3KMe3, which marks for poised enhancer sites. The locus conserved in the mammalian genome also contains DNaseI hyperactivity clusters, which are crucial for transcription factor binding, which initiates and regulates gene expression. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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