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Volume 23, Issue 1, Pages (March 2016)

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1 Volume 23, Issue 1, Pages 51-59 (March 2016)
Sexually dimorphic proteinuria in Wistar rats: Relevance to clinical models  Eseigbe Christian Imafidon, Rufus Ojo Akomolafe, Abraham Ayodele Oladele  Pathophysiology  Volume 23, Issue 1, Pages (March 2016) DOI: /j.pathophys Copyright © 2016 Elsevier B.V. Terms and Conditions

2 Fig. 1 Experimental protocol.
n=number of rats per group; AC=after acclimatization; and *=point at which rats were sacrificed. Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions

3 Fig. 2 Bar chart depicting sexual dimorphism in total urine protein (mg/mL), body weight (g) and protein/100g bodyweight (mg) of the rats. Each value represents mean±S.E.M (n=5); *=significantly different from group 1 (p<0.05); #=significantly different from group 2 (p<0.05); §=significantly different from group 3 (p<0.05). Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions

4 Fig. 3 Bar chart depicting sexual dimorphism in the (a) circumference of Bowman’s capsule (μm); (b) circumference of glomerulus (μm); (c) diameter of Bowman’s capsule (μm); and (d) diameter of glomerulus (μm) of the rats. Each value represents mean±S.E.M (n=5); *=significantly different from group 1 (p<0.05); #=significantly different from group 2 (p<0.05); §=significantly different from group 3 (p<0.05). Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions

5 Fig. 4 Bar chart depicting sexual dimorphism in the diameter of Bowman’s capsular space (μm) of the rats. Each value represents mean±S.E.M (n=5); *=significantly different from group 1 (p<0.05); #=significantly different from group 2 (p<0.05); §=significantly different from group 3 (p<0.05). Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions

6 Fig. 5 Bar charts depicting sexual dimorphism in the relative kidney weight (%) of the rats. Each value represents mean±S.E.M (n=5); *=significantly different from group 1 (p<0.05); #=significantly different from group 2 (p<0.05); §=significantly different from group 3 (p<0.05). Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions

7 Fig. 6 Bar charts depicting sexual dimorphism in (a) plasma creatinine (mg/dL); (b) urine creatinine (mg/dL); and (c) level of creatinine clearance (×10−3mL/min) in the rats. Each value represents mean±S.E.M (n=5); *=significantly different from group 1 (p<0.05); #=significantly different from group 2 (p<0.05); §=significantly different from group 3 (p<0.05). Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions

8 Fig. 7 Bar charts depicting sexual dimorphism in urine protein to creatinine ratio (mg/g) of the rats. Each value represents mean±S.E.M (n=5); *=significantly different from group 1 (p<0.05); #=significantly different from group 2 (p<0.05); §=significantly different from group 3 (p<0.05). Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions

9 Fig. 8 Photomicrographs of the kidney of the rats showing apparently intact renal corpuscles (magnification ×100). G1=group 1 (male 1); G2=group 2 (female 1); G3=group 3 (male 2); and G4=group 4 (female 2). Pathophysiology  , 51-59DOI: ( /j.pathophys ) Copyright © 2016 Elsevier B.V. Terms and Conditions


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