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Volume 59, Issue 4, Pages (April 2001)

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1 Volume 59, Issue 4, Pages 1333-1341 (April 2001)
Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimental to long-term kidney function  Josephine Maree Forbes, Timothy David Hewitson, Gavin James Becker, Colin Lindsay Jones  Kidney International  Volume 59, Issue 4, Pages (April 2001) DOI: /j x Copyright © 2001 International Society of Nephrology Terms and Conditions

2 Figure 1 Functional parameters studied at six-months postischemia. (A) Glomerular filtration rates (GFRs). (B) Urinary protein concentrations. #P < 0.05 as compared with saline ischemic group; *P < 0.05 as compared with sham ischemic group. Standard errors of the mean are shown by the error bars on all graphs (N = 8 for all groups). Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

3 Figure 2 Silver masson trichrome staining of tissue sections. (a) ETA antagonist (SB ) group ×100. (b) ETA antagonist ×400. (c) ETA/ETB antagonist (SB ) group ×100. (d) ETA/ETB ×400. (e) Saline ischemic group 100. (f) Saline ischemic group ×400. (g) Sham ischemic group ×100. (h) Sham ischemic group ×400. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

4 Figure 3 Morphometric quantitation of (A) myofibroblasts (α-SMA) and (B) interstitial collagen III. #P < 0.05 as compared with saline ischemic group; *P < 0.05 as compared with sham ischemic group. Standard errors of the mean are shown by the error bars on all graphs (N = 8 for each group). Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

5 Figure 4 Morphometric quantitation of proliferating (PCNA-positive) cells. *P < 0.05 as compared with sham ischemic group; #P < 0.05 as compared with saline ischemic group (N = 8 for each group). Symbols are: (▪) PCNA total; () tubular; () interstitial; (□) other (refers to vascular and glomerular cells). Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

6 Figure 5 Morphometric quantitation of TUNEL-positive cells. Symbols are: (▪) TUNEL total; () tubular; () interstial. *P < 0.05 as compared with sham ischemic group; #P < 0.05 as compared with saline ischemic group (N = 8 for each group). Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions


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