1. Supplemental Figure 1 1 mutation 2 mutations 3 mutations 4 mutations
Frequency of cases with respective numbers of TP53 mutations per case[%]

2. Numbers of TP53 hotspot mutations in each cohort
Supplemental Figure 2 A
100
nonsense
splice-site
in-frame
frameshift
missense 90 80 70 60
Frequency of TP53 mutation type in relation to the numbers of TP53 mutations in each cohort [%] 50 40 30 20 10
AML ALL CLL MDS B 30
R282
R273
R249
R248
G245
R175 25 20
Numbers of TP53 hotspot mutations in each cohort 15 10 5
AML ALL CLL MDS

3. Frequency of cases with respective TP53 mutation load [%]
Supplemental Figure 3
100
91-100%
81-90%
71-80%
61-70%
51-60%
41-50%
31-40%
21-30%
11-20%
1-10% 90 80 70 60
Frequency of cases with respective TP53 mutation load [%] 50 40 30 20 10
AML ALL CLL MDS