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Actin and Apical Constriction: Some (Re)-Assembly Required

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Presentation on theme: "Actin and Apical Constriction: Some (Re)-Assembly Required"— Presentation transcript:

1 Actin and Apical Constriction: Some (Re)-Assembly Required
Andrew J. Spracklen, Mark Peifer  Developmental Cell  Volume 35, Issue 6, Pages (December 2015) DOI: /j.devcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 F-Actin Turnover Is Critical for Apical Constriction
(A) Apical constriction drives cell shape change and tissue folding. (B) This is achieved by pulsatile cycles of actin- and myosin-driven apical constriction, followed by relaxation. (C) When Cofillin-mediated F-actin disassembly is disrupted, F-actin overaccumulation impairs apical constriction. (D) Profilin is required to promote stable attachment of the contractile machinery to sites of cell-cell contact, helping to achieve force balance. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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